Alcohol Craving and Severity are Associated with Dorsal Anterior Cingulate Choline Levels in Individuals with an Alcohol Use Disorder.
Aims Magnetic resonance spectroscopy (MRS) has been used to probe inflammation in the brain. While altered MRS metabolite levels have previously been found in individuals with alcohol use disorder (AUD), the relationship between potential metabolite markers of inflammation and the clinical correlate...
| Publicado en: | Alcohol & Alcoholism Vol. 58; no. 3; pp. 289 - 298 |
|---|---|
| Autores principales: | , , , , |
| Formato: | diagnostic images research Journal Article |
| Publicado: |
Oxford University Press / USA
May2023
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=163720431&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 163720431 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07350414 FA3 jtl: Alcohol & Alcoholism issn: 07350414 maglogo: N pubinfo: dt: May2023 vid: 58 iid: 3 pid: 622 pub: Oxford University Press / USA artinfo: ui: 163720431 163720431 163720431 10.1093/alcalc/agad014 163720431 ppf: 289 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Alcohol Craving and Severity are Associated with Dorsal Anterior Cingulate Choline Levels in Individuals with an Alcohol Use Disorder. aug: au: Grodin, Erica N Burnette, Elizabeth M O'Neill, Joseph Alger, Jeffry Ray, Lara A affil: Department of Psychology, University of California at Los Angeles , Los Angeles, CA sug: subj: Alcohol-Related Disorders Risk Factors Craving Severity of Illness Choline Blood Cerebral Cortex Physiology Risk Assessment Human Inflammation Magnetic Resonance Spectroscopy Metabolites Exploratory Research Alcohol Abuse Secondary Analysis Questionnaires Creatinine Blood Inositol Blood Phosphocreatine Blood Descriptive Statistics Regression Funding Source ab: Aims Magnetic resonance spectroscopy (MRS) has been used to probe inflammation in the brain. While altered MRS metabolite levels have previously been found in individuals with alcohol use disorder (AUD), the relationship between potential metabolite markers of inflammation and the clinical correlates of AUD remains understudied. Therefore, this exploratory study sought to elucidate the clinical significance of inflammation in AUD by examining relationships between metabolites, AUD severity, alcohol consumption, and craving in individuals with AUD. Methods Data for this secondary analysis are derived from a two-week clinical trial of ibudilast to treat AUD. Forty-three non-treatment-seeking individuals with an AUD (26M/17F) completed an MRS scan and alcohol-related questionnaires. MRS was performed using a multi-voxel array placed above the corpus callosum, extending from the pregnenual anterior cingulate to premotor cortex. The dorsal anterior cingulate was selected as the volume of interest. Metabolite levels of choline-compounds (Cho), myo -inositol (mI), and creatine+phosphocreatine (Cr) were quantified. Separate hierarchical regression models were used to evaluate the independent effects of metabolite levels on alcohol craving, alcohol problem severity, and alcohol consumption. Results Dorsal anterior cingulate Cho predicted alcohol craving and alcohol problem severity over and above demographics, medication, and alcohol consumption measures. mI and Cr did not predict alcohol craving or alcohol problem severity. Metabolite markers were not predictive of alcohol consumption. Conclusions This preliminary study indicates that dACC Cho is sensitive to clinical characteristics of AUD. This is a further step in advancing neurometabolites, particularly Cho, as potential biomarkers and treatment targets for AUD. pubtype: Academic Journal doctype: diagnostic images research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|