Quantifying Alcohol Consumption in the General Population by Analysing Phosphatidylethanol Concentrations in Whole Blood: Results from 24,574 Subjects Included in the HUNT4 Study.
Aims To evaluate the association between self-reported alcohol consumption and phosphatidylethanol (PEth) concentrations in blood in a large general population study, and discuss optimal cut-off PEth concentrations for defined levels of alcohol consumption. Methods Population based, longitudinal coh...
| Publicado en: | Alcohol & Alcoholism Vol. 58; no. 3; pp. 258 - 266 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
May2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=163720432&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 163720432 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07350414 FA3 jtl: Alcohol & Alcoholism issn: 07350414 maglogo: N pubinfo: dt: May2023 vid: 58 iid: 3 pid: 622 pub: Oxford University Press / USA artinfo: ui: 163720432 163720432 163720432 10.1093/alcalc/agad015 163720432 ppf: 258 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Quantifying Alcohol Consumption in the General Population by Analysing Phosphatidylethanol Concentrations in Whole Blood: Results from 24,574 Subjects Included in the HUNT4 Study. aug: au: Skråstad, Ragnhild Bergene Aamo, Trond Oskar Andreassen, Trine Naalsund Havnen, Hilde Hveem, Kristian Krokstad, Steinar Salvesen, Øyvind Spigset, Olav affil: Department of Clinical Pharmacology, St. Olav University Hospital , 7006 Trondheim , Norway sug: subj: Alcohol Drinking Trends Phospholipids Blood Binge Drinking Risk Factors Risk Assessment Alcohol Abuse Risk Factors Human Prospective Studies Norway Questionnaires Adult Middle Age Descriptive Statistics Sensitivity and Specificity ROC Curve Alcohol Drinking Legislation and Jurisprudence Alcohol Abuse Prevention and Control Adult: 19-44 years Middle Aged: 45-64 years ab: Aims To evaluate the association between self-reported alcohol consumption and phosphatidylethanol (PEth) concentrations in blood in a large general population study, and discuss optimal cut-off PEth concentrations for defined levels of alcohol consumption. Methods Population based, longitudinal cohort study including 24,574 adults from The Trøndelag Health Study 4 (HUNT4) conducted in Trøndelag County, Norway. Data included PEth concentration, self-reported alcohol consumption and CAGE score. Results PEth levels in whole blood increased with the number of alcohol units consumed, the frequency of alcohol consumption, the frequency of binge drinking and the CAGE score (lifetime, i.e. 'have you ever'). The cut-off concentrations with highest combined sensitivity and specificity were 0.057 μmol/l (40 ng/ml) for identification of those consuming >1 alcohol unit per day (sensitivity 86%, specificity 76%), 0.087 μmol/l (61 ng/ml) for consuming >2 units per day (sensitivity 87%, specificity 81%) and 0.122 μmol/l (86 ng/ml) for consuming >3 alcohol units per day (sensitivity 80%, specificity 86%). By defining a CAGE score ≥ 2 as potentially harmful consumption, a cut-off of 0.100 μmol/l (70 ng/ml) identified 52% of all those subjects. Conclusions Cut-off limits of PEth concentrations should take into account the indication for sampling. Using cut-offs for the PEth concentrations of about 0.05 μmol/l (35 ng/ml) and 0.08 μmol/l (56 ng/ml) would identify about 90% of the subjects consuming more than 1 and 2 alcohol units per day, respectively. Concentrations above these cut-offs should lead to a more detailed interview related to alcohol use. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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