Can thiamine substitution restore cognitive function in alcohol use disorder?
Aims While clinical consequences of thiamine deficiency in alcohol use disorder (AUD) are severe, evidence-based recommendations on dosage, type of administration and duration of thiamine substitution (TS), and its' target levels remain sparse. This study aimed to compare the effect of two best prac...
| Publicado en: | Alcohol & Alcoholism Vol. 58; no. 3; pp. 315 - 324 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
May2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=163720434&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 163720434 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07350414 FA3 jtl: Alcohol & Alcoholism issn: 07350414 maglogo: N pubinfo: dt: May2023 vid: 58 iid: 3 pid: 622 pub: Oxford University Press / USA artinfo: ui: 163720434 163720434 163720434 10.1093/alcalc/agad017 163720434 ppf: 315 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Can thiamine substitution restore cognitive function in alcohol use disorder? aug: au: Listabarth, Stephan Vyssoki, Benjamin Marculescu, Rodrig Gleiss, Andreas Groemer, Magdalena Trojer, Armin Harrer, Christine Weber, Sabine König, Daniel affil: Clinical Division of Social Psychiatry , Department of Psychiatry and Psychotherapy, Medical University of Vienna , 1090 Vienna , Austria sug: subj: Alcohol-Related Disorders Drug Therapy Thiamine Administration and Dosage Cognition Functional Status Treatment Outcomes Evaluation Medical Practice Human Funding Source Treatment Duration Thiamine Deficiency Complications Thiamine Blood Comparative Studies Inpatients Blood Analysis Confidence Intervals Memory Task Performance and Analysis Alcohol-Related Disorders Complications Dementia Prevention and Control Cognition Disorders Prevention and Control Korsakoff Syndrome Wernicke's Encephalopathy ab: Aims While clinical consequences of thiamine deficiency in alcohol use disorder (AUD) are severe, evidence-based recommendations on dosage, type of administration and duration of thiamine substitution (TS), and its' target levels remain sparse. This study aimed to compare the effect of two best practice TS regimens on thiamine blood levels (i.e. thiamine pyrophosphate, TPP) and cognitive function. Methods In 50 patients undergoing in-patient alcohol-withdrawal treatment, TPP levels were determined at baseline and end of weeks 1, 2 and 8 following administration of oral TS (3 × 100 mg/day for 7 days followed by 1 × 100 mg/day thereafter) either with or without preceding intravenous TS (3 × 100 mg/day for 5 days). An extensive psychiatric assessment was conducted at baseline, including an evaluation of AUD severity and depressive symptoms. Additionally, cognitive function and depressive symptoms were repeatedly evaluated. Results Relevant increases (mean increase by 100.2 nmol/l [CI 76.5–123.8], P < 0.001) in peripheral blood TPP levels were observed in all patients at the end of weeks 1 and 2. Furthermore, no relevant difference between the intravenous and the oral group was found (average difference between increases: 2.3 nmol/l, P = 0.912). Importantly, an association between the 'extent of the response' to TS and the performance in a memory task was revealed in secondary analyses. Conclusion TS was associated with improving cognitive function in patients with AUD, independently of the substitution regime. Thus, in clinical practice, oral TS might be a sufficient but obligatory medication to prevent cognitive decline in AUD in the absence of Wernicke–Korsakoff Syndrome. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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