Association between an oxidative balance score and mortality: a prospective analysis in the SUN cohort.
Purpose: We aimed to prospectively investigate the association of an overall oxidative balance score (OBS) with all-cause death and cause-specific mortality among participants in the Seguimiento Universidad de Navarra (SUN) Study, a Mediterranean cohort of Spanish graduates. Methods: Using baseline...
| Publicado en: | European Journal of Nutrition Vol. 62; no. 4; pp. 1667 - 1681 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jun2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=163798179&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 163798179 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Jun2023 vid: 62 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 163798179 161848297 163798179 163798179 10.1007/s00394-023-03099-8 163798179 ppf: 1667 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Association between an oxidative balance score and mortality: a prospective analysis in the SUN cohort. aug: au: Talavera-Rodriguez, Irene Fernandez-Lazaro, Cesar I. Hernández-Ruiz, Ángela Hershey, Maria S. Galarregui, Cristina Sotos-Prieto, Mercedes de la Fuente-Arrillaga, Carmen Martínez-González, Miguel Ángel Ruiz-Canela, Miguel affil: Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, C/ Irunlarrea, 31008, Pamplona, Spain sug: subj: Oxidative Stress Cause of Death Human Prospective Studies Spain Life Style Antioxidants Body Mass Index Cox Proportional Hazards Model Male Female Adult Middle Age Descriptive Statistics Confidence Intervals Funding Source Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Purpose: We aimed to prospectively investigate the association of an overall oxidative balance score (OBS) with all-cause death and cause-specific mortality among participants in the Seguimiento Universidad de Navarra (SUN) Study, a Mediterranean cohort of Spanish graduates. Methods: Using baseline information on 12 a priori selected dietary and non-dietary lifestyle pro- and antioxidants exposures—vitamins C and E, β-carotenes, selenium, zinc, heme iron, polyphenols, total antioxidant capacity, body mass index, alcohol, smoking, and physical activity—we constructed an equally weighted OBS categorized into quartiles, with higher scores representing greater antioxidant balance. Cox proportional hazards models were fitted to evaluate the association between the OBS and mortality. Results: A total of 18,561 participants (mean [SD] age, 38.5 [12.4] years; 40.8% males) were included in the analysis. During a median follow-up of 12.2 years (interquartile range 8.3–14.9), 421 deaths were identified, including 80 deaths from cardiovascular disease (CVD), 215 from cancer, and 126 from other causes. After adjustment for potential confounders, the hazard ratios and 95% confidence interval (CIs) between the highest quartile (predominance of antioxidants) vs. the lowest quartile (reference category) were 0.35 (95% CI 0.22–0.54, P-trend < 0.001) for all-cause mortality, 0.18 (95% CI 0.06–0.51, P-trend = 0.001) for CVD mortality, 0.35 (95% CI 0.19–0.65, P-trend = 0.002) for cancer mortality, and 0.45 (95% CI 0.20–1.02, P-trend = 0.054) for other-cause mortality. Conclusion: Our findings suggest a strong inverse association between the OBS and all-cause, CVD, and cancer mortality. Individuals exposed to both antioxidant dietary and lifestyle factors may potentially experience the lowest mortality risk. Study registry number: Dynamic Mediterranean Prospective Cohort: the SUN Project; NCT02669602. https://clinicaltrials.gov/ct2/show/NCT02669602. https://proyectosun.es pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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