Skeletal muscle and erythrocyte redox status is associated with dietary cysteine intake and physical fitness in healthy young physically active men.
Purpose: To investigate the association between redox status in erythrocytes and skeletal muscle with dietary nutrient intake and markers of physical fitness and habitual physical activity (PA). Methods: Forty-five young physically active men were assessed for body composition, dietary nutrient inta...
| Publicado en: | European Journal of Nutrition Vol. 62; no. 4; pp. 1767 - 1783 |
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| Autores principales: | , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jun2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=163798182&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 163798182 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Jun2023 vid: 62 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 163798182 162051681 163798182 163798182 10.1007/s00394-023-03102-2 163798182 ppf: 1767 ppct: 16 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Skeletal muscle and erythrocyte redox status is associated with dietary cysteine intake and physical fitness in healthy young physically active men. aug: au: Papanikolaou, Konstantinos Jamurtas, Athanasios Z. Poulios, Athanasios Tsimeas, Panagiotis Draganidis, Dimitrios Margaritelis, Nikos V. Baloyiannis, Ioannis Papadopoulos, Constantinos Sovatzidis, Apostolos Deli, Chariklia K. Rosvoglou, Anastasia Georgakouli, Kalliopi Tzatzakis, Theofanis Nikolaidis, Michalis G. Fatouros, Ioannis G. affil: Department of Physical Education and Sports Science, University of Thessaly, 42100, Trikala, Greece sug: subj: Men Physical Activity Physical Fitness Evaluation Cysteine Metabolism Food Intake Erythrocytes Metabolism Muscle, Skeletal Metabolism Antioxidants Human Male Adult Secondary Analysis Body Composition Diet Muscle Strength Cardiorespiratory Fitness Glutathione Metabolism Athletic Performance Exercise Intensity Funding Source Adult: 19-44 years Male ab: Purpose: To investigate the association between redox status in erythrocytes and skeletal muscle with dietary nutrient intake and markers of physical fitness and habitual physical activity (PA). Methods: Forty-five young physically active men were assessed for body composition, dietary nutrient intake, muscle strength, cardiorespiratory capacity and habitual PA. Blood and muscle samples were collected to estimate selected redox biomarkers. Partial correlation analysis was used to evaluate the independent relationship of each factor with redox biomarkers. Results: Dietary cysteine intake was positively correlated (p < 0.001) with both erythrocyte (r = 0.697) and muscle GSH (0.654, p < 0.001), erythrocyte reduced/oxidized glutathione ratio (GSH/GSSG) (r = 0.530, p = 0.001) and glutathione reductase (GR) activity (r = 0.352, p = 0.030) and inversely correlated with erythrocyte protein carbonyls (PC) levels (r = − 0.325; p = 0.046). Knee extensors eccentric peak torque was positively correlated with GR activity (r = 0.355; p = 0.031) while, one-repetition maximum in back squat exercise was positively correlated with erythrocyte GSH/GSSG ratio (r = 0.401; p = 0.014) and inversely correlated with erythrocyte GSSG and PC (r = − 0.441, p = 0.006; r = − 0.413, p = 0.011 respectively). Glutathione peroxidase (GPx) activity was positively correlated with step count (r = 0.520; p < 0.001), light (r = 0.406; p = 0.008), moderate (r = 0.417; p = 0.006), moderate-to-vigorous (r = 0.475; p = 0.001), vigorous (r = 0.352; p = 0.022) and very vigorous (r = 0.326; p = 0.035) PA. Muscle GSSG inversely correlated with light PA (r = − 0.353; p = 0.022). Conclusion: These results indicate that dietary cysteine intake may be a critical element for the regulation of glutathione metabolism and redox status in two different tissues pinpointing the independent significance of cysteine for optimal redox regulation. Musculoskeletal fitness and PA levels may be predictors of skeletal muscle, but not erythrocyte, antioxidant capacity. Trial registration: Registry: ClinicalTrials.gov, identifier: NCT03711838, date of registration: October 19, 2018. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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