Ex vivo LPS-stimulated cytokine production is associated with hydration status in community-dwelling middle-to-older-aged adults.
Purpose: Suboptimal hydration has been linked to a variety of adverse health outcomes. Few studies have examined the impact of hydration status on immune function, a plausible physiological mechanism underlying these associations. Therefore, we tested how variation in hydration status was associated...
| Publicado en: | European Journal of Nutrition Vol. 62; no. 4; pp. 1681 - 1691 |
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| Autores principales: | , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jun2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=163798185&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 163798185 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Jun2023 vid: 62 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 163798185 161899761 163798185 163798185 10.1007/s00394-023-03105-z 163798185 ppf: 1681 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Ex vivo LPS-stimulated cytokine production is associated with hydration status in community-dwelling middle-to-older-aged adults. aug: au: Davis, Kristin M Rosinger, Asher Y Murdock, Kyle W affil: Department of Biobehavioral Health, Pennsylvania State University, 219 Biobehavioral Health Building, 16802, University Park, PA, USA sug: subj: Community Living In Middle Age Community Living In Old Age Hydration Status Cytokines Blood Human Middle Age Aged Osmolar Concentration Hematologic Tests Biological Markers Blood Multiple Linear Regression Descriptive Statistics Body Mass Index Dehydration Funding Source Middle Aged: 45-64 years Aged: 65+ years ab: Purpose: Suboptimal hydration has been linked to a variety of adverse health outcomes. Few studies have examined the impact of hydration status on immune function, a plausible physiological mechanism underlying these associations. Therefore, we tested how variation in hydration status was associated with circulating pro-inflammatory cytokine levels and ex vivo lipopolysaccharide (LPS)-stimulated pro-inflammatory cytokine production. Methods: Blood samples were obtained from a community sample of healthy middle-to-older-aged adults (N = 72). These samples were used to assess serum osmolality, a biomarker of hydration status, and markers of immune function including circulating pro-inflammatory cytokines and stimulated pro-inflammatory cytokine production after 4 and 24 h of incubation with LPS. Multiple linear regressions were used to test the association between serum osmolality (as a continuous variable) and markers of immune function at baseline and after 4 and 24 h adjusting for age, sex, and BMI. These models were re-estimated with serum osmolality dichotomized at the cut-off for dehydration (> 300 mOsm/kg). Results: While not significantly associated with circulating cytokines (B = − 0.03, p = 0.09), serum osmolality was negatively associated with both 4 h (B = − 0.05, p = 0.048) and 24 h (B = − 0.05, p = 0.03) stimulated cytokine production when controlling for age, sex, and BMI. Similarly, dehydration was associated with significantly lower cytokine production at both 4 h (B = − 0.54, p = 0.02) and 24 h (B = − 0.51, p = 0.02) compared to adequate hydration. Conclusion: These findings suggest that dehydration may be associated with suppressed immune function in generally healthy middle-to-older aged community-dwelling adults. Further longitudinal research is needed to more clearly define the role of hydration in immune function. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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