Cytotoxicity of Carvotacetones from Sphaeranthus africanus Against Cancer Cells and Their Potential to Induce Apoptosis.
Three carvotacetones (1 – 3) isolated from Sphaeranthus africanus were screened in 60 cancer cell lines at the National Cancer Institute (NCI) within the Developmental Therapeutics Program (DTP). At the concentration of 10−5 M, compound 1 (3,5-diangeloyloxy-7-hydroxycarvotacetone) turned out to be t...
| Publicado en: | Planta Medica Vol. 89; no. 6; pp. 624 - 637 |
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| Autores principales: | , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Georg Thieme Verlag Stuttgart
2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=163887971&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 163887971 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00320943 NH9 jtl: Planta Medica issn: 00320943 maglogo: N pubinfo: dt: 2023 vid: 89 iid: 6 pid: 4536 pub: Georg Thieme Verlag Stuttgart artinfo: ui: 163887971 163887971 163887971 10.1055/a-1988-2207 163887971 ppf: 624 ppct: 13 formats: tig: atl: Cytotoxicity of Carvotacetones from Sphaeranthus africanus Against Cancer Cells and Their Potential to Induce Apoptosis. aug: au: Tran, Huyen Thi Kretschmer, Nadine Huynh, Loi Bauer, Rudolf affil: Department of Pharmacognosy, School of Medicine, Vietnam National University HCM City, Ho Chi Minh City, Vietnam sug: subj: Cell Line, Tumor Drug Effects Plant Extracts Pharmacodynamics Apoptosis Drug Effects Plants, Medicinal Molecular Structure ab: Three carvotacetones (1 – 3) isolated from Sphaeranthus africanus were screened in 60 cancer cell lines at the National Cancer Institute (NCI) within the Developmental Therapeutics Program (DTP). At the concentration of 10−5 M, compound 1 (3,5-diangeloyloxy-7-hydroxycarvotacetone) turned out to be the most active compound against ACHN and UO-31 renal cancer cell lines with growth percent values of − 100% (all cells dead). Compound 2 (3-angeloyloxy-5-[2″,3″-epoxy-2″-methylbutanoyloxy]-7-hydroxycarvotacetone) showed strong effects in SK-MEL-5 melanoma and ACHN renal cancer cells with inhibition values of 93% and 97%, respectively. Compound 3 (3-angeloyloxy-5-[3″-chloro-2″-hydroxy-2″-methylbutanoyloxy]-7-hydroxy-carvotacetone) exhibited a quite strong effect on renal cancer cells with a growth inhibitory effect of 96% against ACHN and UO-31 cells. When treated with five different concentrations of 1 (1 × 10−8 , 1 × 10−7 , 1 × 10−6 , 1 × 10−5 , and 1 × 10−4 M), HOP-92 cells were found to be most sensitive with GI50 , TGI, and LC50 values of 0.17, 0.40, and 0.96 µM, respectively. When using the ApoTox-Glo triplex assay to evaluate the apoptosis inducing effects of seven carvotacetones isolated from S. africanus in CCRF-CEM cells, compounds 1 – 6 increased caspase-3/7 activity with 1, 2 , and 4 (3-angeloyloxy-5,7-dihydroxycarvotacetone) exhibiting the highest activitiy, indicating induction of caspase-dependent apoptosis. pubtype: Periodical doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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