Dual effects of extra virgin olive oil in acute wounds.
Extra virgin olive oil (EVOO) has proved beneficial effects in skin wound healing of chronic lesions; however, the effects of EVOO in acute wounds are not completely understood. This study investigated the effects of short‐term and long‐term administration of a diet rich in EVOO on acute wound heali...
| Publicado en: | Wound Repair & Regeneration Vol. 31; no. 3; pp. 338 - 349 |
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| Autores principales: | , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
May/Jun2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=163911489&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 163911489 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10671927 DPV jtl: Wound Repair & Regeneration issn: 10671927 maglogo: Y pubinfo: dt: May/Jun2023 vid: 31 iid: 3 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 163911489 162864714 163911489 163911489 10.1111/wrr.13082 163911489 ppf: 338 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Dual effects of extra virgin olive oil in acute wounds. aug: au: Donato‐Trancoso, Aline V. de Carvalho Faria, Regina C. de S. Ribeiro, Bianca Nogueira, Jeane S. Atella, Geórgia C. Chen, Lin Romana‐Souza, Bruna affil: Department of Histology and Embryology, Rio de Janeiro State University, Rio de Janeiro, Brazil sug: subj: Acute Disease Wounds and Injuries Diet Therapy Olive Oil Administration and Dosage Wound Healing Evaluation Animal Studies Funding Source Mice Macrophages In Vitro Studies Polyphenols RNA, Messenger Inflammation Cytokines In Vivo Studies Oxidative Stress ab: Extra virgin olive oil (EVOO) has proved beneficial effects in skin wound healing of chronic lesions; however, the effects of EVOO in acute wounds are not completely understood. This study investigated the effects of short‐term and long‐term administration of a diet rich in EVOO on acute wound healing. To check this, mice were fed with a diet rich in EVOO for 1 week (short term), 1 month, or 3 months (long term). The control group received a standard diet. Mouse macrophages were treated in vitro with EVOO or hydroxytyrosol (HT), which is the main EVOO polyphenol. Short‐term administration of an EVOO rich diet in vivo increased lipid peroxidation and mRNA levels of pro‐inflammatory cytokine levels and impaired acute wound closure. In contrast, long‐term administration of an EVOO rich diet resulted in increased mRNA levels of anti‐inflammatory cytokines and enhanced acute wound closure. In both in vivo and in vitro assays, the administration of EVOO or HT resulted in a predominantly anti‐inflammatory macrophage phenotype. In conclusion, a diet rich in EVOO has a positive effect on acute wound healing that is dependent on the duration of EVOO administration. Short‐term EVOO diet supplementation increases oxidative damage and pro‐inflammatory responses, which impaired acute wound closure. On the other hand, long‐term EVOO supplementation reduces oxidative damage and enhances anti‐inflammatory responses, which improved acute wound closure. The effects of EVOO on oxidation and inflammation in acute wounds are linked to the EVOO polyphenol HT. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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