Translating Precision Health for Pediatrics: A Scoping Review.
Precision health aims to personalize treatment and prevention strategies based on individual genetic differences. While it has significantly improved healthcare for specific patient groups, broader translation faces challenges with evidence development, evidence appraisal, and implementation. These...
| Publicado en: | Children Vol. 10; no. 5; pp. 897 - 917 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
MDPI
May2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=163938869&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 163938869 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 22279067 LW6K jtl: Children issn: 22279067 maglogo: N pubinfo: dt: May2023 vid: 10 iid: 5 pid: 97109 pub: MDPI artinfo: ui: 163938869 163938869 163938869 10.3390/children10050897 163938869 ppf: 897 ppct: 20 formats: tig: atl: Translating Precision Health for Pediatrics: A Scoping Review. aug: au: Subasri, Mathushan Cressman, Celine Arje, Danielle Schreyer, Leighton Cooper, Erin Patel, Komal Ungar, Wendy J. Barwick, Melanie Denburg, Avram Hayeems, Robin Z. affil: Child Health Evaluative Sciences Program, The Hospital for Sick Children Research Institute, Toronto, ON M5G 1X8, Canada sug: subj: Individualized Medicine Pediatrics Translations Implementation Science Human Funding Source Systematic Review Scoping Review PubMed Embase Translational Medical Research Cost Effectiveness Analysis Technology Ethics ab: Precision health aims to personalize treatment and prevention strategies based on individual genetic differences. While it has significantly improved healthcare for specific patient groups, broader translation faces challenges with evidence development, evidence appraisal, and implementation. These challenges are compounded in child health as existing methods fail to incorporate the physiology and socio-biology unique to childhood. This scoping review synthesizes the existing literature on evidence development, appraisal, prioritization, and implementation of precision child health. PubMed, Scopus, Web of Science, and Embase were searched. The included articles were related to pediatrics, precision health, and the translational pathway. Articles were excluded if they were too narrow in scope. In total, 74 articles identified challenges and solutions for putting pediatric precision health interventions into practice. The literature reinforced the unique attributes of children and their implications for study design and identified major themes for the value assessment of precision health interventions for children, including clinical benefit, cost-effectiveness, stakeholder values and preferences, and ethics and equity. Tackling these identified challenges will require developing international data networks and guidelines, re-thinking methods for value assessment, and broadening stakeholder support for the effective implementation of precision health within healthcare organizations. This research was funded by the SickKids Precision Child Health Catalyst Grant. pubtype: Academic Journal doctype: research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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