Beta-Blockers and Hypertension: Some Questions and Answers.
Introduction: International guidelines have removed b-blockers from first-line treatment of hypertension, limiting their use to patients with compelling indications. The position of guidelines stems from the results of studies performed with the 1st and 2nd generation of b-blockers, which concluded...
| Publicado en: | High Blood Pressure & Cardiovascular Prevention Vol. 30; no. 3; pp. 191 - 199 |
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| Autores principales: | , , , |
| Formato: | review tables/charts Journal Article |
| Publicado: |
Springer Nature
May2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=164005261&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 164005261 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11209879 1WYI jtl: High Blood Pressure & Cardiovascular Prevention issn: 11209879 maglogo: N pubinfo: dt: May2023 vid: 30 iid: 3 pid: 87227 pub: Springer Nature artinfo: ui: 164005261 163649650 164005261 164005261 10.1007/s40292-023-00576-3 164005261 ppf: 191 ppct: 8 formats: tig: atl: Beta-Blockers and Hypertension: Some Questions and Answers. aug: au: Fici, Francesco Robles, Nicolas Roberto Tengiz, Istemihan Grassi, Guido affil: Department of Cardiovascular Risk, Salamanca University, Salamanca, Spain sug: subj: Hypertension Drug Therapy Cardiovascular Diseases Drug Therapy Adrenergic beta-Antagonists Therapeutic Use Antihypertensive Agents Therapeutic Use Age Factors Blood Pressure Drug Effects Literature Review ab: Introduction: International guidelines have removed b-blockers from first-line treatment of hypertension, limiting their use to patients with compelling indications. The position of guidelines stems from the results of studies performed with the 1st and 2nd generation of b-blockers, which concluded that these drugs have lower cardiovascular protection, compared with other antihypertensive agents. Aim: The aim of our mini review is to answer to some questions about the effect of b-blockers on hypertension and cardiovascular protection and if these effects are different from those of other antihypertensive drugs, particularly in young and elderly patients. Methods: We evaluated the relevant systematic reviews and meta-analyses, which reported the effectiveness of b-blockers on blood pressure and cardiovascular outcomes, compared with placebo/no treatment and with other antihypertensive agents. Results: Beta-blockers, decreased high blood pressure with no significant difference from other common antihypertensive agents. Moreover b-blockers, compared with placebo, lowered the risk of major cardiovascular outcomes, while, compared with other drug classes, the reported results are very heterogeneous. Therefore it is difficult, globally, to find a difference between b-blockers and other drug classes. Conclusions: Rather than looking for differences in the cardiovascular protective effect between b-blockers and other antihypertensive agents, we have to consider the different pathophysiology of hypertension in young [sympathetic hyperactivity] and elderly patients [arterial stiffness, high aortic systolic pressure]. Considering these aspects, non-vasodilating b-blockers are preferred, as first-line, in young/middle aged hypertensive subjects, while vasodilating b-blockers, are most appropriate, in elderly patients, for the favourable hemodynamic profile. pubtype: Academic Journal doctype: review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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