Usefulness of the perfusion index for monitoring the response to intravenous ketamine infusion therapy in patients with complex regional pain syndrome.
Background: This study was performed to compare the perfusion index (PI) between affected and unaffected limbs in patients with complex regional pain syndrome (CRPS); it also evaluated the usefulness of the PI for monitoring the response to intravenous ketamine infusion therapy in such patients. Met...
| Publicado en: | Pain Practice Vol. 23; no. 5; pp. 535 - 543 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Jun2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=164115941&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 164115941 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15307085 HYN jtl: Pain Practice issn: 15307085 maglogo: Y pubinfo: dt: Jun2023 vid: 23 iid: 5 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 164115941 162249374 164115941 164115941 10.1111/papr.13215 164115941 ppf: 535 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Usefulness of the perfusion index for monitoring the response to intravenous ketamine infusion therapy in patients with complex regional pain syndrome. aug: au: Hong, Seung‐Wan Hwang, Min‐Sik Kim, Jae Hun Kim, Minjung Kim, Seong‐Hyop affil: Department of Anaesthesiology and Pain Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea sug: subj: Complex Regional Pain Syndromes Drug Therapy Ketamine Administration and Dosage Infusions, Intravenous Treatment Outcomes Evaluation Extremities Perfusion Index Evaluation Predictive Value of Tests Evaluation Human Male Female Adolescence Adult Middle Age Pain Management Visual Analog Scaling ROC Curve Sensitivity and Specificity Descriptive Statistics Confidence Intervals Funding Source Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Background: This study was performed to compare the perfusion index (PI) between affected and unaffected limbs in patients with complex regional pain syndrome (CRPS); it also evaluated the usefulness of the PI for monitoring the response to intravenous ketamine infusion therapy in such patients. Methods: In total, 46 patients with CRPS in one arm or leg were enrolled in this study. The PIs of the unaffected (PIControl) and affected (PICRPS) limbs were simultaneously evaluated before and after treatment. Results: PICRPS was significantly lower than PIControl at all time points. The change in PI from immediately before to 30 min after intravenous ketamine infusion therapy (TBefore and T30 min, respectively) in the affected limb was significantly correlated with the change in visual analog pain scale (VAS) between the two time points (r = 0.646, p < 0.001). The area under the curve for the changes in VAS and PICRPS between TBefore and T30 min was 0.928. The optimal threshold value for the change in PICRPS between TBefore and T30 min, to distinguish responders with a ≥ 50‐point reduction in VAS score from nonresponders, was 22.60% with a sensitivity of 0.811 (95% CI: 0.774–0.848) and a specificity of 0.889 (95% CI: 0.848–0.930). Thirty‐one patients showed a ≥ 50‐point reduction in VAS score [67% (95% CI: 54%–80%)] and 15 patients showed a < 50‐point reduction in VAS score [33% (95% CI: 20%–46%)]. Thirty patients showed an increased PI ≥ 22.60% [65% (95% CI: 50%–78%)] and 16 patients showed an increased PI < 22.60% [35% (95% CI: 22%–50%)]. Twenty‐seven patients had a ≥ 50‐point reduction in VAS score and an increased PI ≥ 22.60% [59% (95% CI: 44%–74%)]. Eleven patients had shown a < 50‐point pain reduction in VAS score and increased PI < 22.60% [24% (95% CI: 13%–37%)]. Conclusion: The PI significantly differed between affected and unaffected limbs in patients with CRPS. The PI may be useful for monitoring the response to intravenous ketamine therapy in patients with CRPS. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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