Right ventricular hypertrophy in apical hypertrophic cardiomyopathy.
Background: Right ventricular hypertrophy (RVH+) in hypertrophic cardiomyopathy occurs in one third of patients, however, outcomes in apical hypertrophic cardiomyopathy (ApHCM) have not been described. We hypothesized that RVH+ in ApHCM is associated with more ventricular remodeling and dysfunction,...
| Published in: | Echocardiography Vol. 40; no. 6; pp. 515 - 524 |
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| Main Authors: | , , |
| Format: | diagnostic images research tables/charts Journal Article |
| Published: |
Wiley-Blackwell
Jun2023
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=164255395&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 164255395 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07422822 GSE jtl: Echocardiography issn: 07422822 maglogo: Y pubinfo: dt: Jun2023 vid: 40 iid: 6 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 164255395 163511844 164255395 164255395 10.1111/echo.15588 164255395 ppf: 515 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Right ventricular hypertrophy in apical hypertrophic cardiomyopathy. aug: au: Mihos, Christos G. Escolar, Esteban Fernandez, Rafle affil: Columbia University Irving Medical Center, Division of Cardiology, Mount Sinai Heart Institute, Miami Beach Florida,, USA sug: subj: Apical Hypertrophic Cardiomyopathy Complications Hypertrophy, Right Ventricular Complications Ventricular Remodeling Risk Factors Ventricular Dysfunction Risk Factors Adverse Health Care Event Risk Factors Risk Assessment Human Male Female Middle Age Aged Aged, 80 and Over Florida Academic Medical Centers Record Review Retrospective Design Prospective Studies Comparative Studies Echocardiography Atrial Fibrillation Epidemiology Stroke Epidemiology Heart Failure Epidemiology Prevalence Incidence Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: Background: Right ventricular hypertrophy (RVH+) in hypertrophic cardiomyopathy occurs in one third of patients, however, outcomes in apical hypertrophic cardiomyopathy (ApHCM) have not been described. We hypothesized that RVH+ in ApHCM is associated with more ventricular remodeling and dysfunction, and increased adverse events when compared with those without RVH (RVH−). Methods: Ninety‐one ApHCM patients were retrospectively analyzed using 2D and speckle‐tracking echocardiography (64 ± 16 years old, 43% female). RVH+ was defined as wall thickness >5 mm and was present in 23 (25%). Ventricular mechanics were characterized by global longitudinal strain (GLS), RV free wall strain, and myocardial work. Results: New York Heart Association functional class > II, atrial fibrillation, and prior stroke were more prevalent in RVH+. Left ventricular (LV) size and ejection fraction were similar between groups, with greater septal (17 vs. 14 mm, p =.001) and apical (20 vs. 18 mm, p =.04) wall thickness in RVH+. When compared with RVH− patients, RVH+ had worse LV GLS (−8.6 vs. −12.8%), global work index (820 vs. 1172 mmHg%) (both p <.001), and work efficiency (76 vs. 83%, p =.001), as well as RV GLS (−14 vs. −17.5%) and free wall strain (−17.3 vs. −21.3%) (both p =.02). At 3‐year follow‐up RVH+ had greater incidence of heart failure hospitalization compared with RVH− (35 vs. 7%, p =.003). RVH+ was associated with RV GLS (β =.2, p =.03), independent of clinical and echocardiographic variables. Conclusions: RVH+ patients with ApHCM have worse biventricular mechanics and myocardial work, and more heart failure hospitalization, as RVH− at mid‐term follow‐up. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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