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Differential target multiplexed spinal cord stimulator: a review of preclinical/clinical data and hardware advancement.

Spinal cord stimulation (SCS) is an effective neuromodulation technique for treating chronic neuropathic pain. Recent rapid growth in understanding its mechanism has led to the development of glial cell-based differential target multiplexed (DTM) stimulation and its derivative algorithm. Both precli...

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Published in:Pain Management Vol. 13; no. 4; pp. 233 - 243
Main Authors: Murphy, Melissa Z, Fishman, Michael A
Format: pictorial review tables/charts Journal Article
Published: Taylor & Francis Ltd Apr2023
Online Access:View this record in EBSCOhost
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      dt: Apr2023
      vid: 13
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      pub: Taylor & Francis Ltd
      place: Philadelphia, Pennsylvania
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        10.2217/pmt-2022-0052
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        atl: Differential target multiplexed spinal cord stimulator: a review of preclinical/clinical data and hardware advancement.
      aug:
        au:
          Murphy, Melissa Z
          Fishman, Michael A
        affil: North Texas Orthopedics & Spine Center, Grapevine, TX 76051, USA
      sug:
        subj:
          Spinal Cord Stimulation Methods
          Chronic Pain Therapy
          Neuralgia Therapy
          Algorithms
          Glial Cells
          Low Back Pain
          Upper Extremity
          Pain Management
      ab: Spinal cord stimulation (SCS) is an effective neuromodulation technique for treating chronic neuropathic pain. Recent rapid growth in understanding its mechanism has led to the development of glial cell-based differential target multiplexed (DTM) stimulation and its derivative algorithm. Both preclinical research and clinical trials in humans showed superior pain relief using DTM SCS compared with traditional SCS. Another multicenter prospective clinical trial showed significant pain score reduction and energy saving using the DTM derivative algorithm. This review paper summarizes the evidence related to using DTM stimulation for other painful conditions such as nonsurgical low back pain and upper-limb pain. All these advanced programming options can be delivered using an innovative platform, the Medtronic Intellis™ neurostimulator.
      pubtype: Academic Journal
      doctype:
        pictorial
        review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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