Atricephenols A and B, two phenolic compounds from Indigofera atriceps Hook.f. (Fabaceae).
The phytochemical investigation of a previously unstudied species of the genus Indigofera, I. atriceps Hook.f. was undertaken and two new phenolic compounds, atricephenols A (1) and B (2) were isolated, along with nine known secondary metabolites viz., (-)-melilotocarpan D (3), genistein (4), melilo...
| Publicado en: | Natural Product Research Vol. 37; no. 14; pp. 2319 - 2327 |
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| Autores principales: | , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Taylor & Francis Ltd
Jul2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=164367217&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 164367217 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14786419 RFT jtl: Natural Product Research issn: 14786419 maglogo: Y pubinfo: dt: Jul2023 vid: 37 iid: 14 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 164367217 155289286 10.1080/14786419.2022.2041007 164367217 ppf: 2319 ppct: 8 formats: tig: atl: Atricephenols A and B, two phenolic compounds from Indigofera atriceps Hook.f. (Fabaceae). aug: au: Mouafon, Iliassou Lah Mountessou, Bel Youssouf Gbetnkom Lateef, Mehreen Tchamgoue, Joseph Shaiq Ali, Muhammad Tchouankeu, Jean Claude Green, Ivan Robert Ngadjui, Bonaventure Tchaleu Kouam, Simeon Fogue affil: Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon sug: ab: The phytochemical investigation of a previously unstudied species of the genus Indigofera, I. atriceps Hook.f. was undertaken and two new phenolic compounds, atricephenols A (1) and B (2) were isolated, along with nine known secondary metabolites viz., (-)-melilotocarpan D (3), genistein (4), melilotocarpan A (5), maackiain (6), p-hydroxybenzaldehyde (7), bornesitol (8), β-sitosterol (9), sitosterol-3-O-β-D-glucopyranoside (10) and stigmasterol-3-O-β-D-glucopyranoside (11). Their structures were elucidated by extensive NMR spectroscopic analyses and HRESIMS, and by comparing their data with those reported in the literature. Compounds 1, 4, 7–11 were tested for their antibacterial efficacies and for their potential to inhibit the enzyme urease. Compounds 7 and 9 showed significant antibacterial activity against Salmonella typhi (ZOIs of 13 and 15 mm, respectively), while the best urease inhibition was measured for compound 9 with an IC50 value of 18.6 µM, which is higher than that of the potent inhibitor, thiourea (IC50 = 21.5 µM). pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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