Dapagliflozin reduces risk of heart failure rehospitalization in diabetic acute myocardial infarction patients: a propensity score-matched analysis.
Objective: The aim of this study was to investigate the effect of dapagliflozin (DAPA) on the rate of heart failure rehospitalization in patients with acute myocardial infarction (AMI) and type 2 diabetes mellitus (T2DM). Methods: AMI patients with T2DM from CZ-AMI registry between January 2017 and...
| Publicado en: | European Journal of Clinical Pharmacology Vol. 79; no. 7; pp. 915 - 927 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jul2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=164373294&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 164373294 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00316970 NP9 jtl: European Journal of Clinical Pharmacology issn: 00316970 maglogo: N pubinfo: dt: Jul2023 vid: 79 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 164373294 163333034 164373294 164373294 10.1007/s00228-023-03495-3 164373294 ppf: 915 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Dapagliflozin reduces risk of heart failure rehospitalization in diabetic acute myocardial infarction patients: a propensity score-matched analysis. aug: au: Mao, Lipeng Cai, Dabei Chi, Boyu Xiao, Tingting Zou, Ailin Wang, Yu Chen, Qianwen Gu, Qingqing Wang, Qingjie Ji, Yuan Sun, Ling affil: Department of Cardiology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, 29 Xinglong Alley, 213000, Changzhou, Jiangsu, China sug: subj: Myocardial Infarction Drug Therapy Diabetes Mellitus, Type 2 Drug Therapy Dapagliflozin Therapeutic Use Heart Failure Epidemiology Heart Failure Risk Factors Readmission Evaluation Drug Efficacy Evaluation Risk Assessment Human China Comparative Studies Kaplan-Meier Estimator Cox Proportional Hazards Model Descriptive Statistics Multivariate Analysis Confidence Intervals Survival Analysis Funding Source ab: Objective: The aim of this study was to investigate the effect of dapagliflozin (DAPA) on the rate of heart failure rehospitalization in patients with acute myocardial infarction (AMI) and type 2 diabetes mellitus (T2DM). Methods: AMI patients with T2DM from CZ-AMI registry between January 2017 and January 2021 were enrolled in this study. Patients were stratified into DAPA users and non-DAPA users. The primary outcome was the incidence of heart failure rehospitalization. Kaplan–Meier analysis and Cox regressions were performed to evaluate the prognostic significance of DAPA. Propensity score matching (PSM) was performed to minimize the bias of confounding factors and facilitate the comparability between groups. The enrolled patients were matched with a propensity score of 1:1. Results: A total of 961 patients were included, and 132 (13.74%) heart failure rehospitalizations occurred during a median follow-up of 540 days. In the Kaplan–Meier analysis, DAPA users had a statistically significantly lower rate of heart failure rehospitalization than non-DAPA users (p < 0.0001). Multivariate Cox analysis showed that DAPA was an independent protective factor for heart failure rehospitalization risk after discharge (HR = 0.498, 95% CI = 0.296 ~ 0.831, p = 0.001). After 1:1 propensity score matching, survival analysis showed a lower cumulative risk of heart failure rehospitalization in DAPA users than in non-DAPA users (p = 0.0007). In-hospital and continued use of DAPA remained significantly associated with a reduced risk of heart failure rehospitalization (HR = 0.417, 95% CI = 0.417 ~ 0.838, p = 0.001). Results were consistent across sensitivity and subgroup analyses. Conclusion: In patients with diabetic AMI, in-hospital and continued use of DAPA after discharge were associated with a significant lower risk of heart failure rehospitalization. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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