An Automated TW3-RUS Bone Age Assessment Method with Ordinal Regression-Based Determination of Skeletal Maturity.

The assessment of bone age is important for evaluating child development, optimizing the treatment for endocrine diseases, etc. And the well-known Tanner-Whitehouse (TW) clinical method improves the quantitative description of skeletal development based on setting up a series of distinguishable stag...

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Publicado en:Journal of Digital Imaging Vol. 36; no. 3; pp. 1001 - 1016
Autores principales: Zhang, Dongxu, Liu, Bowen, Huang, Yulin, Yan, Yang, Li, Shaowei, He, Jinshui, Zhang, Shuyun, Zhang, Jun, Xia, Ningshao
Formato: diagnostic images equations & formulas research tables/charts Journal Article
Publicado: Springer Nature Jun2023
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Jun2023
      vid: 36
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      pub: Springer Nature
      place: New York, New York
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        10.1007/s10278-023-00794-0
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        atl: An Automated TW3-RUS Bone Age Assessment Method with Ordinal Regression-Based Determination of Skeletal Maturity.
      aug:
        au:
          Zhang, Dongxu
          Liu, Bowen
          Huang, Yulin
          Yan, Yang
          Li, Shaowei
          He, Jinshui
          Zhang, Shuyun
          Zhang, Jun
          Xia, Ningshao
        affil: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, 361000, Xiamen, Fujian, China
      sug:
        subj:
          Age Determination by Skeleton Methods
          Diagnosis, Computer Assisted
          Bone Development In Infancy and Childhood
          Bone Development In Adolescence
          Funding Source
          Human
          Radius Radiography
          Ulna Radiography
          Fingers Radiography
          Metacarpal Bones Radiography
          Descriptive Statistics
          Male
          Female
          Deep Learning
          Neural Networks (Computer)
          Regression
          Algorithms
          Radiographic Image Enhancement
          Models, Statistical
          Logistic Regression
          China
          Child, Preschool
          Child
          Adolescence
          Child, Preschool: 2-5 years
          Child: 6-12 years
          Adolescent: 13-18 years
          Male
          Female
      ab: The assessment of bone age is important for evaluating child development, optimizing the treatment for endocrine diseases, etc. And the well-known Tanner-Whitehouse (TW) clinical method improves the quantitative description of skeletal development based on setting up a series of distinguishable stages for each bone individually. However, the assessment is affected by rater variability, which makes the assessment result not reliable enough in clinical practice. The main goal of this work is to achieve a reliable and accurate skeletal maturity determination by proposing an automated bone age assessment method called PEARLS, which is based on the TW3-RUS system (analysis of the radius, ulna, phalanges, and metacarpal bones). The proposed method comprises the point estimation of anchor (PEA) module for accurately localizing specific bones, the ranking learning (RL) module for producing a continuous stage representation of each bone by encoding the ordinal relationship between stage labels into the learning process, and the scoring (S) module for outputting the bone age directly based on two standard transform curves. The development of each module in PEARLS is based on different datasets. Finally, corresponding results are presented to evaluate the system performance in localizing specific bones, determining the skeletal maturity stage, and assessing the bone age. The mean average precision of point estimation is 86.29%, the average stage determination precision is 97.33% overall bones, and the average bone age assessment accuracy is 96.8% within 1 year for the female and male cohorts.
      pubtype: Academic Journal
      doctype:
        diagnostic images
        equations & formulas
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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