A Pilot Controlled Feeding Trial Modifying Protein Intake in Healthy Subjects to Assess Adherence and the Metabolome.
Dietary protein has been shown to impact physiology and pathophysiology, including inflammation and cancer, effects believed to occur through host and microbe-mediated mechanisms. However, the majority of studies investigating this concept have been conducted in animal models, with less information...
| Publicado en: | Nutrition & Cancer Vol. 75; no. 7; pp. 1499 - 1511 |
|---|---|
| Autores principales: | , , , , , , , , |
| Formato: | clinical trial research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
2023
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=164582067&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 164582067 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: 2023 vid: 75 iid: 7 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 164582067 164007327 164582067 164582067 10.1080/01635581.2023.2217542 164582067 ppf: 1499 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: A Pilot Controlled Feeding Trial Modifying Protein Intake in Healthy Subjects to Assess Adherence and the Metabolome. aug: au: Connolly-Schoonen, Josephine Danowski, Lorraine Bistricer, Melissa Campo Catalan, Leslie Ailawadi, Sarina Sicinski, Emily M. Schoonen, Martien Ingram, Brian Montrose, David C. affil: Department of Family, Population & Preventive Medicine, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA sug: subj: Dietary Proteins Food Intake Health Behavior Evaluation Metabolomics Diet Methods Human Pilot Studies Prospective Studies Self Report Hematologic Tests Feces Analysis Macronutrients Amino Acids Analysis Comparative Studies Metabolites Evaluation Clinical Trials Funding Source Male Female Male Female ab: Dietary protein has been shown to impact physiology and pathophysiology, including inflammation and cancer, effects believed to occur through host and microbe-mediated mechanisms. However, the majority of studies investigating this concept have been conducted in animal models, with less information on the optimal approach, tolerability and biologic effects of modifying protein intake in humans. The current study presents a longitudinal controlled feeding trial carried out in healthy humans to acutely modulate protein intake using individualized diets. Adherence to study diets was monitored through subject-reported electronic picture-based assessments and global metabolomic analysis was performed on serum and stool, following each diet stage. Subjects exhibited strong adherence to study diets, with macronutrient intake meeting study goals during each stage. Metabolomic analysis revealed shifts in both serum and feces in association with modifying protein intake, including reciprocal changes in the abundance of amino acids and amino-acid related compounds, when comparing high to reduced protein stages. Additional fecal metabolite changes consisted of reduced microbial fermentation products following the reduced protein diet stage. Collectively, this study provides a robust method to precisely modify and monitor protein intake in humans, as well as assess corresponding metabolomic alterations. pubtype: Academic Journal doctype: clinical trial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|