Dose-related adaptive reconstruction of DMN in isoflurane administration: a study in the rat.
Background: The anesthetic states are accompanied by functional alterations. However, the dose-related adaptive alterations in the higher-order network under anesthesia, e. g. default mode network (DMN), are poorly revealed. Methods: We implanted electrodes in brain regions of the rat DMN to acquire...
| Publicado en: | BMC Anesthesiology Vol. 23; no. 1; pp. 1 - 13 |
|---|---|
| Autores principales: | , , , , , , , , , , , |
| Formato: | equations & formulas research tables/charts Journal Article |
| Publicado: |
BioMed Central
6/28/2023
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=164607930&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 164607930 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14712253 1CH3 jtl: BMC Anesthesiology issn: 14712253 maglogo: N pubinfo: dt: 6/28/2023 vid: 23 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 164607930 164607930 164607930 10.1186/s12871-023-02153-6 164607930 ppf: 1 ppct: 12 formats: tig: atl: Dose-related adaptive reconstruction of DMN in isoflurane administration: a study in the rat. aug: au: Guo, Fengru Li, Yuqin Jian, Zhaoxin Cui, Yan Gong, Wenhui Li, Airui Jing, Wei Xu, Peng Chen, Ke Guo, Daqing Yao, Dezhong Xia, Yang affil: Department of Neurosurgery, MOE Key Lab for Neuroinformation, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, 611731, Chengdu, China sug: subj: Default Mode Network Drug Effects Isoflurane Administration and Dosage Adaptation, Physiological Animal Studies Rats Funding Source Electrodes, Implanted Brain Physiology Anesthesia Functional Connectivity Evaluation Physics Neural Networks (Computer) Local Field Potential Measurement ab: Background: The anesthetic states are accompanied by functional alterations. However, the dose-related adaptive alterations in the higher-order network under anesthesia, e. g. default mode network (DMN), are poorly revealed. Methods: We implanted electrodes in brain regions of the rat DMN to acquire local field potentials to investigate the perturbations produced by anesthesia. Relative power spectral density, static functional connectivity (FC), fuzzy entropy of dynamic FC, and topological features were computed from the data. Results: The results showed that adaptive reconstruction was induced by isoflurane, exhibiting reduced static and stable long-range FC, and altered topological features. These reconstruction patterns were in a dose-related fashion. Conclusion: These results might impart insights into the neural network mechanisms underlying anesthesia and suggest the potential of monitoring the depth of anesthesia based on the parameters of DMN. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|