Effect of perioperative high‐dose transdermal nicotine patch on pain sensitivity among male abstinent tobacco smokers undergoing abdominal surgery: A randomized controlled pilot study.
Background and Aims: Previous studies have focused on the role of perioperative nicotine replacement therapy (NRT) in improving the success rate of long‐term smoking cessation in tobacco smokers. This study aimed to measure the effectiveness of high‐dose NRT in alleviating postoperative pain for mal...
| Publicado en: | Addiction Vol. 118; no. 8; pp. 1579 - 1586 |
|---|---|
| Autores principales: | , , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Wiley-Blackwell
Aug2023
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=164656281&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 164656281 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09652140 AIO jtl: Addiction issn: 09652140 maglogo: Y pubinfo: dt: Aug2023 vid: 118 iid: 8 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 164656281 163773132 164656281 164656281 10.1111/add.16224 164656281 ppf: 1579 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Effect of perioperative high‐dose transdermal nicotine patch on pain sensitivity among male abstinent tobacco smokers undergoing abdominal surgery: A randomized controlled pilot study. aug: au: Zhu, Chengcheng Bi, Yanzhi Wei, Kai Tao, Kunming Hu, Li Lu, Zhijie affil: Department of Anesthesiology, Shanghai Eastern Hepatobiliary Surgery Hospital, Shanghai, China sug: subj: Perioperative Care Transdermal Patches, Drugs Therapeutic Use Nicotine Administration and Dosage Postoperative Pain Prevention and Control Pain Threshold Drug Effects Smoking Cessation Abdomen Surgery Men's Health Treatment Outcomes Human Male Female Hospitals China Randomized Controlled Trials Random Assignment Pilot Studies Double-Blind Studies Analgesia Tobacco Smoking Morphine Incidence Nicotine Replacement Therapy Nausea Complications Vomiting Complications Fever Complications Postoperative Complications Descriptive Statistics Funding Source Male Female ab: Background and Aims: Previous studies have focused on the role of perioperative nicotine replacement therapy (NRT) in improving the success rate of long‐term smoking cessation in tobacco smokers. This study aimed to measure the effectiveness of high‐dose NRT in alleviating postoperative pain for male abstinent smokers receiving abdominal surgery. Design: This was a parallel‐group, randomized, double‐blind and controlled pilot trial. Setting and participants: In total, 101 male smoking‐abstinent patients from the Eastern Hepatobiliary Surgery Hospital, Shanghai, China, from 8 October 2018 to 10 December 2021. Interventions: Patients started smoking cessation on admission to the hospital ward. Patients received 24‐hour transdermal nicotine patches (n = 50) or placebo (n = 51) every day from admission until 48 hours after surgery. Measurements The primary outcomes were pre‐surgery pain thresholds and total consumption of analgesics within the first 48 hours after surgery. Secondary outcomes included postoperative pain and sedation scores, nausea, vomiting and fever frequency within the treatment period. Findings Both pre‐surgery electrical and mechanical pain thresholds in the NRT group were higher than those in the placebo group (P = 0.004 and P = 0.020, respectively). The 48‐hour postoperative analgesic consumption was significantly lower for smoking‐abstinent patients receiving NRT than those receiving placebo (standardized morphine equivalent requirement, median [interquartile range], 1.80 [1.47, 2.32] mg/kg vs 2.22 [1.62, 2.82] mg/kg, P = 0.011). Postoperative pain intensity was significantly lower in the NRT group than that in the placebo group at 1st hour and 24th hour post‐surgery (P < 0.001 and P = 0.012, respectively). The incidence of treatment‐related adverse events was not significantly different between groups. Conclusions: Perioperative high‐dose nicotine replacement therapy may help to relieve postoperative pain among male smoking‐abstinent patients undergoing abdominal surgery. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|