Measurement of an evaporation coefficient in tissue sections as a correction factor for 10B determination.
Boron neutron capture therapy (BNCT) is a cancer treatment option that combines preferential uptake of a boron compound in tumors and irradiation with thermal neutrons. For treatment planning, the boron concentration in different tissues must be considered. Neutron autoradiography using nuclear trac...
| Publicado en: | Histochemistry & Cell Biology Vol. 160; no. 1; pp. 3 - 11 |
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| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Jul2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=164661173&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 164661173 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09486143 NQI jtl: Histochemistry & Cell Biology issn: 09486143 maglogo: N pubinfo: dt: Jul2023 vid: 160 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 164661173 163410545 10.1007/s00418-023-02200-w 164661173 ppf: 3 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Measurement of an evaporation coefficient in tissue sections as a correction factor for 10B determination. aug: au: Espector, Natalia Portu, Agustina Mariana Espain, María Sol Leyva, Gabriela Saint Martin, Gisela affil: Departamento de Radiobiología, Comisión Nacional de Energía Atómica (CNEA), Av. General Paz 1499, San Martin, B1650KNA, Buenos Aires, Argentina sug: ab: Boron neutron capture therapy (BNCT) is a cancer treatment option that combines preferential uptake of a boron compound in tumors and irradiation with thermal neutrons. For treatment planning, the boron concentration in different tissues must be considered. Neutron autoradiography using nuclear track detectors (NTD) can be applied to study both the concentration and microdistribution of boron in tissue samples. Histological sections are obtained from frozen tissue by cryosectioning. When the samples reach room temperature, they undergo an evaporation process, which leads to an increase in the boron concentration. To take this effect into account, certain correction factors (evaporation coefficients, CEv) must be applied. With this aim, a protocol was established to register and analyze mass variation of tissue sections, measured with a semimicro scale. Values of ambient temperature, pressure, and humidity were simultaneously recorded. Reproducible results of evaporation curves and CEv values were obtained for different tissue samples, which allowed the systematization of the procedure. This study could contribute to a more precise determination of boron concentration in tissue samples through the neutron autoradiography technique, which is of great relevance to make dosimetric calculations in BNCT. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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