Towards in vivo characterization of thyroid nodules suspicious for malignancy using multispectral optoacoustic tomography.
Purpose: Patient-tailored management of thyroid nodules requires improved risk of malignancy stratification by accurate preoperative nodule assessment, aiming to personalize decisions concerning diagnostics and treatment. Here, we perform an exploratory pilot study to identify possible patterns on m...
| Publicado en: | European Journal of Nuclear Medicine & Molecular Imaging Vol. 50; no. 9; pp. 2736 - 2751 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Jul2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=164680646&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 164680646 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16197070 NPC jtl: European Journal of Nuclear Medicine & Molecular Imaging issn: 16197070 maglogo: N pubinfo: dt: Jul2023 vid: 50 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 164680646 163019517 10.1007/s00259-023-06189-1 164680646 ppf: 2736 ppct: 15 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Towards in vivo characterization of thyroid nodules suspicious for malignancy using multispectral optoacoustic tomography. aug: au: Noltes, Milou E. Bader, Maximilian Metman, Madelon J. H. Vonk, Jasper Steinkamp, Pieter J. Kukačka, Jan Westerlaan, Henriette E. Dierckx, Rudi A. J. O. van Hemel, Bettien M. Brouwers, Adrienne H. van Dam, Gooitzen M. Jüstel, Dominik Ntziachristos, Vasilis Kruijff, Schelto affil: Department of Surgical Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands sug: ab: Purpose: Patient-tailored management of thyroid nodules requires improved risk of malignancy stratification by accurate preoperative nodule assessment, aiming to personalize decisions concerning diagnostics and treatment. Here, we perform an exploratory pilot study to identify possible patterns on multispectral optoacoustic tomography (MSOT) for thyroid malignancy stratification. For the first time, we directly correlate MSOT images with histopathology data on a detailed level. Methods: We use recently enhanced data processing and image reconstruction methods for MSOT to provide next-level image quality by means of improved spatial resolution and spectral contrast. We examine optoacoustic features in thyroid nodules associated with vascular patterns and correlate these directly with reference histopathology. Results: Our methods show the ability to resolve blood vessels with diameters of 250 μm at depths of up to 2 cm. The vessel diameters derived on MSOT showed an excellent correlation (R2-score of 0.9426) with the vessel diameters on histopathology. Subsequently, we identify features of malignancy observable in MSOT, such as intranodular microvascularity and extrathyroidal extension verified by histopathology. Despite these promising features in selected patients, we could not determine statistically relevant differences between benign and malignant thyroid nodules based on mean oxygen saturation in thyroid nodules. Thus, we illustrate general imaging artifacts of the whole field of optoacoustic imaging that reduce image fidelity and distort spectral contrast, which impedes quantification of chromophore presence based on mean concentrations. Conclusion: We recommend examining optoacoustic features in addition to chromophore quantification to rank malignancy risk. We present optoacoustic images of thyroid nodules with the highest spatial resolution and spectral contrast to date, directly correlated to histopathology, pushing the clinical translation of MSOT. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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