Interrelationships among growth hormone, thyroid function, and endocrine-disrupting chemicals on the susceptibility to attention-deficit/hyperactivity disorder.
Abnormal growth hormones and thyroid function may be linked to pathophysiology of attention-deficit/hyperactivity disorder (ADHD). Phthalates and bisphenol-A (BPA), two endocrine-disrupting chemicals (EDCs), may affect the human endocrine system. In this study, we aimed to perform a comprehensive in...
| Publicado en: | European Child & Adolescent Psychiatry Vol. 32; no. 8; pp. 1391 - 1402 |
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| Autores principales: | , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Aug2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=164747524&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 164747524 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Aug2023 vid: 32 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 164747524 155050257 164747524 164747524 10.1007/s00787-021-01886-4 164747524 ppf: 1391 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Interrelationships among growth hormone, thyroid function, and endocrine-disrupting chemicals on the susceptibility to attention-deficit/hyperactivity disorder. aug: au: Wang, Liang-Jen Huang, Ying-Hua Chou, Wen-Jiun Lee, Sheng-Yu Chang, Hsin-Yu Chen, Chih-Cheng Chao, How-Ran affil: Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan sug: subj: Attention Deficit Hyperactivity Disorder Physiopathology Human Growth Hormone Blood Thyroid Hormones Blood Benzhydryl Compounds Urine Plasticizers Analysis Attention Deficit Hyperactivity Disorder Risk Factors Plasticizers Adverse Effects Benzhydryl Compounds Adverse Effects Risk Assessment Human Case Control Studies Child Somatomedins Blood Thyrotropin Blood Triiodothyronine Blood Thyroxine Blood Plasticizers Connective Tissue Growth Factor Blood Carrier Proteins Blood Urinalysis Attention Deficit Hyperactivity Disorder Symptoms Neuropsychological Tests Descriptive Statistics Female Male Funding Source Child: 6-12 years Female Male ab: Abnormal growth hormones and thyroid function may be linked to pathophysiology of attention-deficit/hyperactivity disorder (ADHD). Phthalates and bisphenol-A (BPA), two endocrine-disrupting chemicals (EDCs), may affect the human endocrine system. In this study, we aimed to perform a comprehensive investigation of whether growth hormone, thyroid function, and EDCs exhibited differential levels between ADHD patients and healthy controls. In total, 144 children with ADHD and 70 healthy control subjects were enrolled. Their endocrine systems were evaluated using the serum levels of insulin-like growth factor-1 (IGF-1), IGF-binding protein-3 (IGFBP-3), thyroid-stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4), and Free T4. The urinary levels of EDCs, including monoethyl phthalate (MEP), mono-methyl phthalate (MMP), monoethylhexyl phthalate (MEHP), mono-n-butyl phthalate (MnBP), monobenzyl phthalate (MBzP), and BPA, were also examined. Patients with ADHD had lower IGF-1 levels than healthy controls (p = 0.003), but we observed no significant difference in IGFBP-3, TSH, T3, T4, or Free T4. Compared to the control group, patients with ADHD demonstrated higher MEHP levels (p = 0.043), MnBP (p = 0.033), and MBzP (p = 0.040). Furthermore, MEHP levels (p < 0.001) and BPA levels (p = 0.041) were negatively correlated with IGF-1 levels, while IGF-1 levels were negatively correlated with principal components consisting of ADHD clinical symptoms and neuropsychological performance variables. We suggest that MEHP exposure may be associated with decreased serum levels of IGF-1 and increased risk of ADHD. The mechanism underlying this association may be important for protecting children from environmental chemicals that adversely affect neurodevelopment. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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