Concurrent and Prospective Associations of Reward Response with Affective and Alcohol Problems: ADHD-Related Differential Vulnerability.
Attention-deficit/hyperactivity disorder (ADHD) is a heterogeneous disorder. Data on the role of transdiagnostic, intermediate phenotypes in ADHD-relevant characteristics and outcomes are needed to advance conceptual understanding and approaches to precision psychiatry. Specifically, the extent to w...
| Published in: | Journal of Youth & Adolescence Vol. 52; no. 9; pp. 1856 - 1873 |
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| Main Authors: | , , , , , |
| Format: | Article |
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Springer Nature
Sep2023
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| Subjects: | |
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=164782909&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 164782909 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00472891 JYA jtl: Journal of Youth & Adolescence issn: 00472891 maglogo: N pubinfo: dt: Sep2023 vid: 52 iid: 9 pid: 237 pub: Springer Nature artinfo: ui: 164782909 10.1007/s10964-023-01794-7 ppf: 1856 ppct: 17 formats: fmt: – @attributes: type: T – @attributes: type: P size: 1.2MB tig: atl: Concurrent and Prospective Associations of Reward Response with Affective and Alcohol Problems: ADHD-Related Differential Vulnerability. aug: au: Rádosi, Alexandra Ágrez, Kristóf Pászthy, Bea Réthelyi, János M. Ulbert, István Bunford, Nóra affil: Clinical and Developmental Neuropsychology Research Group, Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Budapest, Hungary Doctoral School of Mental Health Sciences, Semmelweis University, Budapest, Hungary Department of Pediatrics, Semmelweis University, Budapest, Hungary Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary Integrative Neuroscience Research Group, Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Budapest, Hungary Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Budapest, Hungary su: Risk factors of attention-deficit hyperactivity disorder Affective disorders Reward (Psychology) Adolescence Brain physiology Alcohol-induced disorders Magnetic resonance imaging Descriptive statistics Research funding sug: subj: Risk factors of attention-deficit hyperactivity disorder Affective disorders Reward (Psychology) Adolescence Diagnostic Imaging Centers Brain physiology Alcohol-induced disorders Magnetic resonance imaging Descriptive statistics Research funding keyword: ADHD Affect Alcohol Reinforcement sensitivity ADHD Affect Alcohol Reinforcement sensitivity ab: Attention-deficit/hyperactivity disorder (ADHD) is a heterogeneous disorder. Data on the role of transdiagnostic, intermediate phenotypes in ADHD-relevant characteristics and outcomes are needed to advance conceptual understanding and approaches to precision psychiatry. Specifically, the extent to which the association between neural response to reward and ADHD-associated affective, externalizing, internalizing, and substance use problems differ depending on ADHD status is unknown. Aims were to examine, in 129 adolescents, whether concurrent and prospective associations of fMRI-measured initial response to reward attainment (relative to loss) with affectivity and externalizing, internalizing, and alcohol use problems differs between youth at-risk for (i.e., subclinical) (n = 50) and not at-risk for ADHD. Adolescents were, on average, 15.29 years old (SD = 1.00; 38% female), 50 were at-risk for (M = 15.18 years, SD = 1.04; 22% female) and 79 not at-risk for (M = 15.37 years, SD = 0.98; 48.1% female) ADHD. Both concurrent and prospective relations differed given ADHD risk: across analyses, in at-risk youth, greater superior frontal gyrus response was associated with lower concurrent depressive problems but in not at-risk youth, these characteristics were not related. Controlling for baseline use, in at-risk youth, greater putamen response was associated with greater 18-month hazardous alcohol use, whereas in not at-risk youth, greater putamen response was associated with lower use. Where in brain and for which outcomes modulate (direction of) observed relations: superior frontal gyrus response is relevant for depressive problems whereas putamen response is relevant for alcohol problems and greater neural responsivity is linked to less depressive but to more alcohol problems in adolescents at-risk for ADHD and less alcohol problems in adolescents not at-risk. Differences in neural response to reward differentially confer vulnerability for adolescent depressive and alcohol problems depending on ADHD risk. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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