Two Neuroanatomical Signatures in Schizophrenia: Expression Strengths Over the First 2 Years of Treatment and Their Relationships to Neurodevelopmental Compromise and Antipsychotic Treatment.
Background and Hypothesis Two machine learning derived neuroanatomical signatures were recently described. Signature 1 is associated with widespread grey matter volume reductions and signature 2 with larger basal ganglia and internal capsule volumes. We hypothesized that they represent the neurodeve...
| Published in: | Schizophrenia Bulletin Vol. 49; no. 4; pp. 1067 - 1078 |
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| Main Authors: | , , , , , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Oxford University Press / USA
Jul2023
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=164799052&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 164799052 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 05867614 2CZ jtl: Schizophrenia Bulletin issn: 05867614 maglogo: N pubinfo: dt: Jul2023 vid: 49 iid: 4 pid: 622 pub: Oxford University Press / USA artinfo: ui: 164799052 164799052 164799052 10.1093/schbul/sbad040 164799052 ppf: 1067 ppct: 11 formats: tig: atl: Two Neuroanatomical Signatures in Schizophrenia: Expression Strengths Over the First 2 Years of Treatment and Their Relationships to Neurodevelopmental Compromise and Antipsychotic Treatment. aug: au: Plessis, Stefan du Chand, Ganesh B Erus, Guray Phahladira, Lebogang Luckhoff, Hilmar K Smit, Retha Asmal, Laila Wolf, Daniel H Davatzikos, Christos Emsley, Robin affil: Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University , Tygerberg Campus, Cape Town , South Africa sug: subj: Schizophrenia Drug Therapy Antipsychotic Agents Therapeutic Use Treatment Duration Neurodevelopment Neuroanatomy Gene Expression Profiling Treatment Outcomes Evaluation Human Correlational Studies Machine Learning Psychiatric Patients Academic Performance Cognition Sensory Motor Integration Memory Functional Status Problem Solving Body Mass Index Severity of Illness Indices Schizophrenia Symptoms Funding Source ab: Background and Hypothesis Two machine learning derived neuroanatomical signatures were recently described. Signature 1 is associated with widespread grey matter volume reductions and signature 2 with larger basal ganglia and internal capsule volumes. We hypothesized that they represent the neurodevelopmental and treatment-responsive components of schizophrenia respectively. Study Design We assessed the expression strength trajectories of these signatures and evaluated their relationships with indicators of neurodevelopmental compromise and with antipsychotic treatment effects in 83 previously minimally treated individuals with a first episode of a schizophrenia spectrum disorder who received standardized treatment and underwent comprehensive clinical, cognitive and neuroimaging assessments over 24 months. Ninety-six matched healthy case–controls were included. Study Results Linear mixed effect repeated measures models indicated that the patients had stronger expression of signature 1 than controls that remained stable over time and was not related to treatment. Stronger signature 1 expression showed trend associations with lower educational attainment, poorer sensory integration, and worse cognitive performance for working memory, verbal learning and reasoning and problem solving. The most striking finding was that signature 2 expression was similar for patients and controls at baseline but increased significantly with treatment in the patients. Greater increase in signature 2 expression was associated with larger reductions in PANSS total score and increases in BMI and not associated with neurodevelopmental indices. Conclusions These findings provide supporting evidence for two distinct neuroanatomical signatures representing the neurodevelopmental and treatment-responsive components of schizophrenia. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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