Magnetic resonance elastography-derived stiffness: potential imaging biomarker for differentiation of benign and malignant pancreatic masses.
Objective: This study sought to determine the diagnostic performance of magnetic resonance elastography (MRE) for pancreatic solid masses, compared with diffusion-weighted imaging (DWI) and serum CA19-9, to establish a threshold for differentiating between pancreatic ductal adenocarcinoma (PDAC) and...
| Published in: | Abdominal Radiology Vol. 48; no. 8; pp. 2604 - 2615 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Published: |
Springer Nature
Aug2023
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=164801561&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 164801561 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: Aug2023 vid: 48 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 164801561 163908831 10.1007/s00261-023-03956-4 164801561 ppf: 2604 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Magnetic resonance elastography-derived stiffness: potential imaging biomarker for differentiation of benign and malignant pancreatic masses. aug: au: Liu, Dingxia Chen, Jiejun Zhang, Yunfei Dai, Yongming Yao, Xiuzhong affil: Shanghai Institute of Medical Imaging, Fudan University, Shanghai, China sug: ab: Objective: This study sought to determine the diagnostic performance of magnetic resonance elastography (MRE) for pancreatic solid masses, compared with diffusion-weighted imaging (DWI) and serum CA19-9, to establish a threshold for differentiating between pancreatic ductal adenocarcinoma (PDAC) and benign tumors in pancreas. Materials and methods: Between July 2021 to January 2023, 75 adult patients confirmed with pancreatic solid tumors were enrolled in this prospective and consecutive study. All patients underwent MRE and DWI examinations that were both performed with a spin echo-EPI sequence. Stiffness maps and apparent diffusion coefficient (ADC) maps were generated, with MRE-derived mass stiffness and stiffness ratio (computing as the ratio of mass stiffness to the parenchyma stiffness) and DWI-derived ADC values obtained by placing regions of interest over the focal tumors on stiffness and ADC maps. Further analysis of comparing diagnostic performances was assessed by calculating the area under ROC curves. Results: PDAC had significantly higher tumor stiffness [3.795 (2.879–4.438) kPa vs. 2.359 (2.01–3.507) kPa, P = 0.0003], stiffness ratio [1.939 (1.562–2.511) vs. 1.187 (1.031–1.453), P < 0.0001] and serum CA19-9 level [276 (31.73–1055) vs. 10.45 (7.825–14.15), P < 0.0001] than other pancreatic masses. Mass stiffness, stiffness ratio and serum CA19-9 showed good diagnostic performance for differentiation with AUC of 0.7895, 0.8392 and 0.9136 respectively. The sensitivity/specificity/positive predictive value/negative predictive value for differentiating malignant from benign pancreatic tumors with mass stiffness (cutoff, > 2.8211 kPa) and stiffness ratio (cutoff, > 1.5117) were 78.4/66.7/82.9/60% and 77.8/83.3/90.3/65.2% respectively. The combined performance of Mass stiffness, stiffness ratio and serum CA19-9 got an AUC of 0.9758. Conclusion: MRE holds excellent clinical potential in discriminating pancreatic ductal adenocarcinoma from other pancreatic solid masses according to their mechanical properties. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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