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Research Progress Into Adipose Tissue Macrophages and Insulin Resistance.

In recent years, there has been an increasing incidence of metabolic syndrome, type 2 diabetes, and cardiovascular events related to insulin resistance. As one of the target organs for insulin, adipose tissue is essential for maintaining in vivo immune homeostasis and metabolic regulation. Currently...

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Published in:Physiological Research Vol. 72; no. 3; pp. 287 - 300
Main Authors: Mengfei FU, Liu YANG, Hanyu WANG, Yang CHEN, Xiao CHEN, Qinyu HU, Hui SUN
Format: Journal Article
Published: Institute of Physiology, Academy of Sciences of the Czech Republic Jun2023
Online Access:View this record in EBSCOhost
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      dt: Jun2023
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      pub: Institute of Physiology, Academy of Sciences of the Czech Republic
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        atl: Research Progress Into Adipose Tissue Macrophages and Insulin Resistance.
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        au:
          Mengfei FU
          Liu YANG
          Hanyu WANG
          Yang CHEN
          Xiao CHEN
          Qinyu HU
          Hui SUN
        affil: Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
      sug:
      ab: In recent years, there has been an increasing incidence of metabolic syndrome, type 2 diabetes, and cardiovascular events related to insulin resistance. As one of the target organs for insulin, adipose tissue is essential for maintaining in vivo immune homeostasis and metabolic regulation. Currently, the specific adipose tissue mechanisms involved in insulin resistance remain incompletely understood. There is increasing evidence that the process of insulin resistance is mostly accompanied by a dramatic increase in the number and phenotypic changes of adipose tissue macrophages (ATMs). In this review, we discuss the origins and functions of ATMs, some regulatory factors of ATM phenotypes, and the mechanisms through which ATMs mediate insulin resistance. We explore how ATM phenotypes contribute to insulin resistance in adipose tissue. We expect that modulation of ATM phenotypes will provide a novel strategy for the treatment of diseases associated with insulin resistance.
      pubtype: Academic Journal
      doctype: Journal Article
      ougenre: Article
    language: English
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