Ultrasound Imaging with Flexible Array Transducer for Pancreatic Cancer Radiation Therapy.
Simple Summary: Ultrasound (US) imaging has been widely used for tumor tracking in image-guided radiotherapy. The quality of US images using conventional probes highly depends on user proficiency and anatomical changes, which has severely hindered the use of US-based organ motion monitoring for panc...
| Published in: | Cancers Vol. 15; no. 13; pp. 3294 - 3314 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | diagnostic images equations & formulas pictorial research tables/charts Journal Article |
| Published: |
MDPI
Jul2023
|
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=164924244&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 164924244 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20726694 B74B jtl: Cancers issn: 20726694 maglogo: N pubinfo: dt: Jul2023 vid: 15 iid: 13 pid: 97109 pub: MDPI artinfo: ui: 164924244 164924244 164924244 10.3390/cancers15133294 164924244 ppf: 3294 ppct: 20 formats: tig: atl: Ultrasound Imaging with Flexible Array Transducer for Pancreatic Cancer Radiation Therapy. aug: au: Huang, Xinyue Hooshangnejad, Hamed China, Debarghya Feng, Ziwei Lee, Junghoon Bell, Muyinatu A. Lediju Ding, Kai affil: Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21287, USA sug: subj: Pancreatic Neoplasms Radiotherapy Radiation Dosage Transducers Evaluation Algorithms Utilization Gastrointestinal Neoplasms Radiotherapy Human In Vivo Studies Experimental Studies Pancreatic Neoplasms Ultrasonography Phantoms, Imaging Abdomen Motion Evaluation Monitoring, Physiologic Funding Source ab: Simple Summary: Ultrasound (US) imaging has been widely used for tumor tracking in image-guided radiotherapy. The quality of US images using conventional probes highly depends on user proficiency and anatomical changes, which has severely hindered the use of US-based organ motion monitoring for pancreatic cancer. The flexible array transducer is a novel and promising solution to address the limitation of conventional US probes. At the same time, its strength and flexible geometry also makes the image reconstruction and delay-and-sum (DAS) beamforming very challenging. Inaccuracy in delay calculation results in defocused and distorted US images. In this study, we proposed a novel shape estimation for flexible array transducer to enhance abdomen motion monitoring. Pancreatic cancer with less than 10% 3-year survival rate is one of deadliest cancer types and greatly benefits from enhanced radiotherapy. Organ motion monitoring helps spare the normal tissue from high radiation and, in turn, enables the dose escalation to the target that has been shown to improve the effectiveness of RT by doubling and tripling post-RT survival rate. The flexible array transducer is a novel and promising solution to address the limitation of conventional US probes. We proposed a novel shape estimation for flexible array transducer using two sequential algorithms: (i) an optical tracking-based system that uses the optical markers coordinates attached to the probe at specific positions to estimate the array shape in real-time and (ii) a fully automatic shape optimization algorithm that automatically searches for the optimal array shape that results in the highest quality reconstructed image. We conducted phantom and in vivo experiments to evaluate the estimated array shapes and the accuracy of reconstructed US images. The proposed method reconstructed US images with low full-width-at-half-maximum (FWHM) of the point scatters, correct aspect ratio of the cyst, and high-matching score with the ground truth. Our results demonstrated that the proposed methods reconstruct high-quality ultrasound images with significantly less defocusing and distortion compared with those without any correction. Specifically, the automatic optimization method reduced the array shape estimation error to less than half-wavelength of transmitted wave, resulting in a high-quality reconstructed image. pubtype: Academic Journal doctype: diagnostic images equations & formulas pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|