Association of Dual-Task Gait Cost and White Matter Hyperintensity Burden Poststroke: Results From the ONDRI.
Background: Acute change in gait speed while performing a mental task [dual-task gait cost (DTC)], and hyperintensity magnetic resonance imaging signals in white matter are both important disability predictors in older individuals with history of stroke (poststroke). It is still unclear, however, wh...
| Publicado en: | Neurorehabilitation & Neural Repair Vol. 37; no. 7; pp. 434 - 444 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
Jul2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=164942150&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 164942150 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15459683 IRK jtl: Neurorehabilitation & Neural Repair issn: 15459683 maglogo: Y pubinfo: dt: Jul2023 vid: 37 iid: 7 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 164942150 164036106 164942150 164942150 10.1177/15459683231177606 164942150 ppf: 434 ppct: 10 formats: tig: atl: Association of Dual-Task Gait Cost and White Matter Hyperintensity Burden Poststroke: Results From the ONDRI. aug: au: Pieruccini-Faria, Frederico Cornish, Benjamin Binns, Malcolm Fraser, Julia Haddad, Seyyed M. H. Sunderland, Kelly Ramirez, Joel Beaton, Derek Kwan, Donna Dilliott, Allison A. Scott, Christopher Sarquis-Adamson, Yanina Black, Alanna Van Ooteghem, Karen Casaubon, Leanne Dowlatshahi, Dar Hassan, Ayman Mandzia, Jennifer Sahlas, Demetrios Saposnik, Gustavo affil: Gait and Brain Lab, St. Joseph's Hospital, Parkwood Institute, Lawson Health Research Institute, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada sug: subj: Gait Analysis White Matter Pathology Task Performance and Analysis Stroke Complications Magnetic Resonance Imaging Human Prospective Studies Cross Sectional Studies Stroke Patients Ontario Basal Ganglia Pathology Thalamus Pathology Cognition Stroke Etiology Accelerometry Walking Speed Middle Age Aged Aged, 80 and Over Atrophy Data Analysis Software Descriptive Statistics Linear Regression Mediation Analysis Female Male Funding Source Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Female Male ab: Background: Acute change in gait speed while performing a mental task [dual-task gait cost (DTC)], and hyperintensity magnetic resonance imaging signals in white matter are both important disability predictors in older individuals with history of stroke (poststroke). It is still unclear, however, whether DTC is associated with overall hyperintensity volume from specific major brain regions in poststroke. Methods: This is a cohort study with a total of 123 older (69 ± 7 years of age) participants with history of stroke were included from the Ontario Neurodegenerative Disease Research Initiative. Participants were clinically assessed and had gait performance assessed under single- and dual-task conditions. Structural neuroimaging data were analyzed to measure both, white matter hyperintensity (WMH) and normal appearing volumes. Percentage of WMH volume in frontal, parietal, occipital, and temporal lobes as well as subcortical hyperintensities in basal ganglia + thalamus were the main outcomes. Multivariate models investigated associations between DTC and hyperintensity volumes, adjusted for age, sex, years of education, global cognition, vascular risk factors, APOE4 genotype, residual sensorimotor symptoms from previous stroke and brain volume. Results: There was a significant positive global linear association between DTC and hyperintensity burden (adjusted Wilks' λ =.87, P =.01). Amongst all WMH volumes, hyperintensity burden from basal ganglia + thalamus provided the most significant contribution to the global association (adjusted β =.008, η2 =.03; P =.04), independently of brain atrophy. Conclusions: In poststroke, increased DTC may be an indicator of larger white matter damages, specifically in subcortical regions, which can potentially affect the overall cognitive processing and decrease gait automaticity by increasing the cortical control over patients' locomotion. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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