Exploration of thyroglobulin as a biomarker of iodine status in iodine-sufficient and mildly iodine-deficient pregnant women.
Purpose: Urinary iodine-to-creatinine ratio (UI/Creat) reflects recent iodine intake but has limitations for assessing habitual intake. Thyroglobulin (Tg) concentration, which increases with thyroid size, appears to be an indicator of longer-term iodine status in children and adults, however, less i...
| Publicado en: | European Journal of Nutrition Vol. 62; no. 5; pp. 2139 - 2155 |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Aug2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=164947179&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 164947179 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Aug2023 vid: 62 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 164947179 162702021 164947179 164947179 10.1007/s00394-023-03131-x 164947179 ppf: 2139 ppct: 16 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Exploration of thyroglobulin as a biomarker of iodine status in iodine-sufficient and mildly iodine-deficient pregnant women. aug: au: Dineva, Mariana Rayman, Margaret P. Levie, Deborah Hunziker, Sandra Guxens, Mònica Peeters, Robin P. Murcia, Mario Rebagliato, Marisa Irizar, Amaia Jimeno-Romero, Alba Sunyer, Jordi Korevaar, Tim I. M. Bath, Sarah C. affil: Department of Nutritional Sciences, Faculty of Health and Medical Sciences, University of Surrey, GU2 7XH, Guildford, UK sug: subj: Iodine Deficiency Diet Therapy Globulins Blood Biological Markers Iodine Urine Nutritional Status Expectant Mothers Psychosocial Factors Pregnancy Complications Prevention and Control Iodine Therapeutic Use Human Female Adult Pregnancy Netherlands Spain Multiple Regression Models, Theoretical Sociodemographic Factors Diet Smoking Mann-Whitney U Test Kruskal-Wallis Test Spearman's Rank Correlation Coefficient Chi Square Test Multivariate Analysis Data Analysis Software Descriptive Statistics Funding Source Adult: 19-44 years Female ab: Purpose: Urinary iodine-to-creatinine ratio (UI/Creat) reflects recent iodine intake but has limitations for assessing habitual intake. Thyroglobulin (Tg) concentration, which increases with thyroid size, appears to be an indicator of longer-term iodine status in children and adults, however, less is known in pregnancy. This study investigated the determinants of serum-Tg in pregnancy and its use as an iodine-status biomarker in settings of iodine-sufficiency and mild-to-moderate deficiency. Methods: Stored blood samples and existing data from pregnant women from the Netherlands-based Generation R (iodine-sufficient) and the Spain-based INMA (mildly-to-moderately iodine-deficient) cohorts were used. Serum-Tg and iodine status (as spot-urine UI/Creat) were measured at median 13 gestational weeks. Using regression models, maternal socio-demographics, diet and iodine-supplement use were investigated as determinants of serum-Tg, as well as the association between UI/Creat and serum-Tg. Results: Median serum-Tg was 11.1 ng/ml in Generation R (n = 3548) and 11.5 ng/ml in INMA (n = 1168). When using 150 µg/g threshold for iodine deficiency, serum-Tg was higher in women with UI/Creat < 150 vs ≥ 150 µg/g (Generation R, 12.0 vs 10.4 ng/ml, P = 0.010; INMA, 12.8 vs 10.4 ng/ml, P < 0.001); after confounder adjustment, serum-Tg was still higher when UI/Creat < 150 µg/g (regression coefficients: Generation R, B = 0.111, P = 0.050; INMA, B = 0.157, P = 0.010). Iodine-supplement use and milk intake were negatively associated with serum-Tg, whereas smoking was positively associated. Conclusion: The association between iodine status and serum-Tg was stronger in the iodine-deficient cohort, than in the iodine-sufficient cohort. Serum-Tg might be a complementary (to UI/Creat) biomarker of iodine status in pregnancy but further evidence is needed. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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