Does thiamine supplementation affect heart failure? A systematic review and meta-analysis of randomized control trials.
• There are about six randomized control trial which emphasize thiamine supplementation effects on heart failure related symptoms. • Although thiamine has optimistic impact on improving cardiac functions and thiamine status but this systemic review and meta-analysis does not find any pronounced chan...
| Publicado en: | Heart & Lung Vol. 61; pp. 37 - 46 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research systematic review Journal Article |
| Publicado: |
Elsevier B.V.
Sep2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=164961393&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 164961393 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01479563 04L jtl: Heart & Lung issn: 01479563 maglogo: N pubinfo: dt: Sep2023 vid: 61 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 164961393 164961393 164961393 10.1016/j.hrtlng.2023.04.011 164961393 ppf: 37 ppct: 9 formats: tig: atl: Does thiamine supplementation affect heart failure? A systematic review and meta-analysis of randomized control trials. aug: au: Syed, Abdul Rehman Shah Syed, Abdul Ahad Akram, Abdullah Azam, Muhammad Shaheryar Muzammil, Muhammad Ali Deepak Ansari, Ayesha Irshad Eqbal, Farea Farooq, Muhammad Haris Khatri, Mahima Kumar, Satesh Kumar, Nomesh affil: Dow University of Health Science (Medicine), H#2 G#50/4/2/2 Umar banglows Abdul Rehman street garden east, Karachi, Pakistan sug: subj: Thiamine Deficiency Complications Hypertension Complications Smoking Complications Obesity Complications Heart Failure Risk Factors Thiamine Dietary Supplementation Heart Failure Prevention and Control Risk Assessment Human Systematic Review Meta Analysis Descriptive Statistics Data Analysis Software ab: • There are about six randomized control trial which emphasize thiamine supplementation effects on heart failure related symptoms. • Although thiamine has optimistic impact on improving cardiac functions and thiamine status but this systemic review and meta-analysis does not find any pronounced change on the outcome which correlates with HF except heart rate. • Multicenter control trials with large population are needed to acknowledge the effect of thiamine supplementation. Heart failure is a pathophysiological condition where decreased cardiac output is observed subsequent to any structural deformity or cessation of normal function. Thiamine deficiency is one of the risk factors responsible for causing HF; other risk factors include hypertension, smoking, and obesity. We conducted a systemic review and meta-analysis of RCTs to scrutinize whether the heart failure patients would benefit from thiamine supplementation or not when compared to placebo. We selected only those double-arm randomized controlled trials (RCTs) which included participants presenting with symptomatic heart failure. We excluded all the articles published in languages other than English Language. Furthermore, all the studies other than RCTs were also omitted. Articles yielded from the electronic search were exported to EndNote Reference Library software to remove any duplicates. Analyses were done using the Review manager 5.4 tool. Mean values and standard deviations were retrieved for the continuous outcomes given as raw data. The 6 RCTs selected for the statistical analysis consisted of 298 participants (158 in the intervention group, 140 in the placebo group). The outcomes resulted to be non-significant with LVEF p-value= 0.08, NT-pro BNP p-value= 0.94, LVEDV p-value= 0.53, 6MWT p-value=0.59, mortality p-value= 0.61, hospitalization p-value= 0.53 and dyspnea p-value= 0.77. Heart rate is the only significant outcome with a p-value=0.04. To conclude, except for heart rate, thiamine supplementation had no effect on the outcomes of heart failure patients. pubtype: Academic Journal doctype: meta analysis research systematic review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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