Pyoderma gangrenosum and peripheral arterial disease: a case series and literature review.
Background Pyoderma gangrenosum (PG) is a neutrophilic dermatosis associated with systemic inflammatory diseases. Peripheral arterial disease (PAD) is a manifestation of atherosclerosis, which is a chronic inflammatory disease. Hypothesis Is the presence of PAD a risk factor for the prognosis of PG?...
| Publicado en: | Journal of Wound Management Vol. 24; no. 2; pp. 14 - 19 |
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| Autores principales: | , , |
| Formato: | case study pictorial research tables/charts Journal Article |
| Publicado: |
Cambridge Publishing
Jul2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=164968703&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 164968703 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 27885771 MZEQ jtl: Journal of Wound Management issn: 27885771 maglogo: N pubinfo: dt: Jul2023 vid: 24 iid: 2 pid: 66266 pub: Cambridge Publishing artinfo: ui: 164968703 164968703 164968703 10.35279/jowm2023.24.02.05 164968703 ppf: 14 ppct: 5 formats: fmt: @attributes: type: P tig: atl: Pyoderma gangrenosum and peripheral arterial disease: a case series and literature review. aug: au: Caixinha, Adriana L. Fogh, Karsten Bech, Rikke affil: Department of Dermatology and Venereology, Aarhus University Hospital, Aarhus, Denmark sug: subj: Pyoderma Gangrenosum Prognosis Pyoderma Gangrenosum Risk Factors Peripheral Vascular Diseases Complications Risk Assessment Human Female Male Middle Age Aged Aged, 80 and Over Retrospective Design Record Review Medical Records Amputation Body Mass Index Biopsy Prednisolone Administration and Dosage Mycophenolate Mofetil Administration and Dosage Methotrexate Administration and Dosage Infliximab Administration and Dosage Treatment Duration Treatment Outcomes Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Female Male ab: Background Pyoderma gangrenosum (PG) is a neutrophilic dermatosis associated with systemic inflammatory diseases. Peripheral arterial disease (PAD) is a manifestation of atherosclerosis, which is a chronic inflammatory disease. Hypothesis Is the presence of PAD a risk factor for the prognosis of PG? Methods We performed a retrospective medical chart review of seven patients with an overlap of PAD and PG and compared treatment strategies and outcomes. Results Six out of seven patients had a poor outcome, requiring amputation, even though adequate treatment was initiated. Conclusions We propose that PAD, whether by reducing the healing potential or by partially contributing to the pathophysiology of the wounds, is a risk factor for the prognosis of PG. Furthermore, the fact that three of the patients developed PAD within a very short period of time after the diagnosis of PG suggests that PG could itself be a risk factor for the development of PAD. However, more clinical data is required to adequately assess this possible relation. Implications for clinical practice Raise awareness to the possible co-existency of both diagnoses and the importance of early screening. pubtype: Academic Journal doctype: case study pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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