EP122 TREATMENT OF CHRONIC WOUNDS IN ISCHEMIC LOWER EXTREMITIES WITH NOVEL FISH SKIN--DERIVED MATRIX: A PROSPECTIVE, RANDOMIZED, CONTROLLED STUDY...European Wound Management Association (EWMA) Conference, May 3-5, 2023, Milan, Italy.

Aim: To evaluate the efficacy of treatment in the chronic wounds of patients with ischemia of the lower extremities, we compared an omega-3 wound matrix product (Kerecis, Isafjordur, Iceland) with a standard dressing. Method: We performed a single-center, prospective, randomized, controlled clinical...

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Publicado en:Journal of Wound Management Vol. 24; no. 2; pp. 97 - 99
Autores principales: Hyung-Sup Shim, Hyeju Han
Formato: abstract pictorial proceedings research tables/charts randomized controlled trial Journal Article
Publicado: Cambridge Publishing Jul2023
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Jul2023
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      pub: Cambridge Publishing
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        atl: EP122 TREATMENT OF CHRONIC WOUNDS IN ISCHEMIC LOWER EXTREMITIES WITH NOVEL FISH SKIN--DERIVED MATRIX: A PROSPECTIVE, RANDOMIZED, CONTROLLED STUDY...European Wound Management Association (EWMA) Conference, May 3-5, 2023, Milan, Italy.
      aug:
        au:
          Hyung-Sup Shim
          Hyeju Han
        affil: The Catholic University of Korea, St. Vincent's Hospital, Suwon, Korea, Rep. of South
      sug:
        subj:
          Wounds, Chronic Therapy
          Ischemia
          Lower Extremity Pathology
          Fatty Acids, omega-3 Therapeutic Use
          Fish Therapeutic Use
          Skin Transplantation
          Allografts
          Bandages and Dressings
          Treatment Outcomes Evaluation
          Congresses and Conferences Italy
          Italy
      ab: Aim: To evaluate the efficacy of treatment in the chronic wounds of patients with ischemia of the lower extremities, we compared an omega-3 wound matrix product (Kerecis, Isafjordur, Iceland) with a standard dressing. Method: We performed a single-center, prospective, randomized, controlled clinical trial of patients with a wound that failed to heal following 3 weeks of conservative care. The ischemic condition was confirmed as decreased transcutaneous oxygen pressure (TcPO2) < 40 mmHg. After randomizing patients into a case and a control group, the weekly decrease in wound area over 12 weeks and the number of patients that achieved complete wound closure were compared between the two groups. Patients with TcPO2≤32 mmHg were further extracted to analysis in a severe ischemic context. Results / Discussion: 28 patients were assigned to the case group and 22 patients to the control group. During 12 weeks, the wound area decreased more rapidly in the case group than the control group. Complete wound healing occurred in 82% in the case group and 45% in the control group. Even in patients with a severe ischemic wound with TcPO2 value < 32 mmHg, wound area decreased more rapidly in the case group than the control group. The proportions of epithelized area in the groups were 80.24% and 57.44%, respectively. Conclusion: Considering the more rapid decrease in wound area and complete healing ratio in the case group, application of a fish skin--derived matrix for treating lower-extremity chronic wounds, especially in chronic wounds in ischemic lower extremities, is a good treatment option.
      pubtype: Academic Journal
      doctype:
        abstract
        pictorial
        proceedings
        research
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        randomized controlled trial
        Journal Article
      ougenre: Article
    language: English
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