Role of psychological background in cancer susceptibility genetic testing distress: It is not only about a positive result.
Clinical and familial factors predict psychological distress after genetic testing for cancer susceptibility. However, the contribution of an individual's psychological background to such distress is unclear. This study aims to analyze the psychological impact of genetic testing and to identify the...
| Publicado en: | Journal of Genetic Counseling Vol. 32; no. 4; pp. 778 - 788 |
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| Autores principales: | , , , , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Aug2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=169726998&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 169726998 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10597700 41A jtl: Journal of Genetic Counseling issn: 10597700 maglogo: N pubinfo: dt: Aug2023 vid: 32 iid: 4 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 169726998 161709029 169726998 169726998 10.1002/jgc4.1687 169726998 ppf: 778 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Role of psychological background in cancer susceptibility genetic testing distress: It is not only about a positive result. aug: au: López‐Fernández, Adrià Villacampa, Guillermo Salinas, Mònica Grau, Elia Darder, Esther Carrasco, Estela Solanes, Ares Velasco, Angela Torres, Maite Munté, Elisabet Iglesias, Silvia Torres‐Esquius, Sara Tuset, Noemí Diez, Orland Lázaro, Conxi Brunet, Joan Corbella, Sergi Balmaña, Judith affil: Hereditary Cancer Genetics Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain sug: subj: Disease Susceptibility Neoplasms Genetic Screening Psychosocial Factors Risk Assessment Human Psychological Distress Prospective Studies Multicenter Studies Personality Worry Questionnaires Uncertainty Patient Attitudes Multivariate Analysis Descriptive Statistics Female Male Holistic Care Funding Source Female Male ab: Clinical and familial factors predict psychological distress after genetic testing for cancer susceptibility. However, the contribution of an individual's psychological background to such distress is unclear. This study aims to analyze the psychological impact of genetic testing and to identify the profile of individuals at higher risk. This is a longitudinal multicenter study of individuals undergoing genetic testing for cancer susceptibility. Demographic, clinical, genetic, familial, and psychological (personality types, cancer worry) characteristics were assessed by validated questionnaires the day of genetic testing. Distress, uncertainty, and positive experience perception (MICRA scale) were evaluated at the results disclosure visit, and 3 and 12 months afterwards. Multivariate analysis was performed. A total of 714 individuals were included. A high neuroticism score, high baseline cancer worry, and a positive genetic test result were independently associated with higher psychological impact (p‐value < 0.05). The highest risk profile (10% of the cohort) included women with high level of neuroticism and a positive result. Uncertainty was mainly associated with a high level of neuroticism, regardless of the genetic test result. A holistic approach to personalized germline genetic counseling should include the assessment of personality dimensions. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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