Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus.

BACKGROUND: Numerous laboratory tests are used in the diagnosis and management of diabetes mellitus. The quality of the scientific evidence supporting the use of these assays varies substantially. APPROACH: An expert committee compiled evidencebased recommendations for laboratory analysis in screeni...

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Publicado en:Clinical Chemistry Vol. 69; no. 8; pp. 808 - 869
Autores principales: Sacks, David B., Arnold, Mark, Bakris, George L., Bruns, David E., Horvath, Andrea R., Lernmark, Åke, Metzger, Boyd E., Nathan, David M., Kirkman, M. Sue
Formato: Journal Article
Publicado: Oxford University Press / USA Aug2023
Acceso en línea:Ver este registro en EBSCOhost
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        atl: Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus.
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          Sacks, David B.
          Arnold, Mark
          Bakris, George L.
          Bruns, David E.
          Horvath, Andrea R.
          Lernmark, Åke
          Metzger, Boyd E.
          Nathan, David M.
          Kirkman, M. Sue
        affil: Department of Laboratory Medicine, National Institutes of Health, Bethesda, MD, United States
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      ab: BACKGROUND: Numerous laboratory tests are used in the diagnosis and management of diabetes mellitus. The quality of the scientific evidence supporting the use of these assays varies substantially. APPROACH: An expert committee compiled evidencebased recommendations for laboratory analysis in screening, diagnosis, or monitoring of diabetes. The overall quality of the evidence and the strength of the recommendations were evaluated. The draft consensus recommendations were evaluated by invited reviewers and presented for public comment. Suggestions were incorporated as deemed appropriate by the authors (see Acknowledgments). The guidelines were reviewed by the Evidence Based Laboratory Medicine Committee and the Board of Directors of the American Association of Clinical Chemistry and by the Professional Practice Committee of the American Diabetes Association. CONTENT: Diabetes can be diagnosed by demonstrating increased concentrations of glucose in venous plasma or increased hemoglobin A1c (Hb A1c) in the blood. Glycemic control is monitored by the people with diabetes measuring their own blood glucose with meters and/or with continuous interstitial glucose monitoring (CGM) devices and also by laboratory analysis of Hb A1c. The potential roles of noninvasive glucose monitoring, genetic testing, and measurement of ketones, autoantibodies, urine albumin, insulin, proinsulin, and C-peptide are addressed. SUMMARY: The guidelines provide specific recommendations based on published data or derived from expert consensus. Several analytes are found to have minimal clinical value at the present time, and measurement of them is not recommended.
      pubtype: Academic Journal
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    language: English
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