Evaluating Serum Proteome in Women with Obsessive-Compulsive Disorder/Bipolar Disorder Compared to Pure Obsessive- Compulsive Disorder Subjects and Healthy Controls.
Objectives The present study aimed to evaluate the serum proteome of women with obsessive-compulsive disorder (OCD)/bipolar disorder (BP) compared to pure OCD subjects and healthy controls. Materials & Methods Serum proteome of women with OCD/BP, pure OCD individuals, and healthy controls were subje...
| Publicado en: | Iranian Journal of Child Neurology Vol. 17; no. 3; pp. 133 - 143 |
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| Autores principales: | , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Iranian Journal of Child Neurology
Summer2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=169841519&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 169841519 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17354668 A91T jtl: Iranian Journal of Child Neurology issn: 17354668 maglogo: N pubinfo: dt: Summer2023 vid: 17 iid: 3 pid: 56766 pub: Iranian Journal of Child Neurology place: Tehran, <Blank> artinfo: ui: 169841519 169841519 169841519 10.22037/ijcn.v17i1.34795 169841519 ppf: 133 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Evaluating Serum Proteome in Women with Obsessive-Compulsive Disorder/Bipolar Disorder Compared to Pure Obsessive- Compulsive Disorder Subjects and Healthy Controls. aug: au: TAHERY, Noorollah REZAEI TAVIRANI, Mostafa ZAMANIAN AZODI, Mona HAMDIEH, Mostafa ROSTAMI NEJAD, Mohammad MAHMOODI, Nahid affil: Nursing Faculty, Abadan University of Medical Sciences, Abadan, Iran sug: subj: Proteomics Evaluation Obsessive-Compulsive Disorder Blood Bipolar Disorder Blood Proteins Blood Serum Analysis Women Psychosocial Factors Human Female Mass Spectrometry Methods Electrophoresis Methods Iran Descriptive Statistics Vitamin D Biological Markers Blood Comparative Studies Carrier Proteins Blood Serum Globulins Analysis Obsessive-Compulsive Disorder Diagnosis Bipolar Disorder Diagnosis Female ab: Objectives The present study aimed to evaluate the serum proteome of women with obsessive-compulsive disorder (OCD)/bipolar disorder (BP) compared to pure OCD subjects and healthy controls. Materials & Methods Serum proteome of women with OCD/BP, pure OCD individuals, and healthy controls were subjected to 2DE-based proteomics accompanied with MALDI-TOF-TOF mass spectrometry. Further evaluation of the identified protein spots with the significance of p<0.05 and fold≥1.5 was done by applying protein interaction mapping via Cytoscape v. 5.3.1 and its plugins. Results The results indicate that vitamin D binding protein (GC) and haptoglobin spots (HP) significantly changed expression in OCD and OCD/BP with different expression patterns. These identified spots may contribute to OCD/BP and act as differentially recognized biomarkers comparing pure OCD and OCD/BP. Conclusion The Findings imply that these proteins in the serum of the patients could be potential distinguishable biomarkers in clinical usage after related validation experiments. Therefore, this study provides a preliminary evaluation to understand OCD/BP proteome behavior better. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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