Evaluation of Serum Uric Acid and its Correlation with Decline in Estimated Glomerular Filtration Rate among the Chronic Kidney Disease Patients.
Background: Chronic kidney disease is one of the most serious public health burdens globally, with significant morbidity, mortality, and reduced patient life expectancy. Many sub-Saharan African countries face double-burden challenges in the treatment of chronic kidney disease and its complications....
| Publicado en: | Africa Journal of Nursing & Midwifery Vol. 25; no. 1; pp. 1 - 17 |
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| Autores principales: | , , |
| Formato: | equations & formulas research tables/charts Journal Article |
| Publicado: |
Unisa Press
2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=169903146&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 169903146 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16825055 Z0G jtl: Africa Journal of Nursing & Midwifery issn: 16825055 maglogo: N pubinfo: dt: 2023 vid: 25 iid: 1 pid: 38319 pub: Unisa Press artinfo: ui: 169903146 169903146 169903146 10.25159/2520-5293/12817 169903146 ppf: 1 ppct: 16 formats: fmt: @attributes: type: P tig: atl: Evaluation of Serum Uric Acid and its Correlation with Decline in Estimated Glomerular Filtration Rate among the Chronic Kidney Disease Patients. aug: au: Seyoum, Fikadu Woldemariam, Maekel Belay Zawdie, Belay affil: Ambo University, Addis Ababa, Ethiopia sug: subj: Uric Acid Blood Glomerular Filtration Rate Evaluation Renal Insufficiency, Chronic Risk Assessment Disease Progression Risk Factors Human Academic Medical Centers Ethiopia Ethiopia Cross Sectional Studies Structured Questionnaires Record Review Physical Examination Pearson's Correlation Coefficient Male Creatinine Blood Female Linear Regression Adult Middle Age Blood Urea Nitrogen Age Factors Blood Pressure Descriptive Statistics Data Analysis Software Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Background: Chronic kidney disease is one of the most serious public health burdens globally, with significant morbidity, mortality, and reduced patient life expectancy. Many sub-Saharan African countries face double-burden challenges in the treatment of chronic kidney disease and its complications. This study aims to evaluate serum uric acid and its correlation with estimated glomerular filtration rate, as well as other risk factors among chronic kidney disease patients on follow-up at Jimma University specialised referral hospital. Method: A hospital-based cross-sectional study was conducted at Jimma University Medical Centre from August 6, 2022, to November 13, 2022. Using a consecutive sampling technique, a total of 140 CKD follow-up patients were recruited into the current study. Data were collected using interviewer-based structured questionnaires, record reviews, and physical examinations. The collected data were analysed by SPSS version 25.0. The correlation between eGFR and uric acid concentrations was examined by Pearson's correlation analyses. Univariate and multivariate linear regression were used to test predictors of serum uric acid in the study participants. Result: A total of 140 study participants were recruited for this study. Subjects included (54.3% [n=76]) men and (45.7% [n=64]) women, respectively. The mean (SD) age of the study subjects was 51.04±9.02 years. The mean value of serum uric acid was 7.2±2.1mg/dl, whereas the mean of estimated glomerular filtration rate (eGFR) was 54.2±31 mL/min/1.73m². Furthermore, the mean values of serum creatinine and blood urea nitrogen among participants in this study were 3.2±1.4 and 67.8±35.8 mg/dL. In the current study, estimated glomerular filtration rate (eGFR) value was negatively correlated (r=-0.912, P<0.001) with uric acid. However, systolic blood pressure was positively correlated (r=0.584, P<0.001) with uric acid. Moreover, the eGFR value was negatively associated (β=-0.060, P=<0.001) with uric acid among study participants. Conclusion: Based on the current study findings, an increase in serum uric acid was associated with a decrease in eGFR value. Increased serum uric acid, increased body mass index (BMI) and high blood pressure are independent risk factors for disease progression in patients with CKD. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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