| Sumario: | • This study demonstrates significant positive effects of HoloPatient-based problem-based learning (PBL) on students' perception of problem-based learning ability, critical thinking disposition, and learning confidence and satisfaction. • HoloPatient used in the PBL approach can offer a motivating environment to help students actively participate in finding and solving the nursing problems by observing and assessing visually and audibly. • MR-based HoloPatient incorporated with PBL can provide students with an opportunity to learn problem-solving skills in realistic nursing work contexts, acquire related nursing knowledge and increase their learning motivation. There has been little investigation of nursing students' experience of MR-based HoloPatient integrated into PBL contexts. A mixed methods design was used to examine the effect of HoloPatient-based PBL in nursing students. This study found significant positive effects of the HoloPatient-based PBL on problem-solving ability, critical thinking disposition, and learning confidence and satisfaction. Two themes were identified for students' experiences in the HoloPatient-based PBL: positive experiences of HoloPatient-based PBL learning, and suggestions for improvement. MR-based HoloPatient incorporated with PBL can allow students to learn problem-solving skills in realistic nursing work contexts, acquire related nursing knowledge and increase their learning motivation.
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