Cortical morphological changes in multiple sclerosis patients: a study of cortical thickness, sulcal depth, and local gyrification index.
Purpose: Multiple sclerosis (MS) is a disease that progresses not only with demyelination but also with neurodegeneration. One of the goals of drug treatment in MS is to prevent neurodegeneration. Cortical thickness (CT), sulcal depth (SD), and local gyrification index (LGI) are indicators related t...
| Publicado en: | Neuroradiology Vol. 65; no. 9; pp. 1405 - 1414 |
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| Autores principales: | , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Sep2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=169945786&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 169945786 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Sep2023 vid: 65 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 169945786 164432440 169945786 169945786 10.1007/s00234-023-03185-y 169945786 ppf: 1405 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Cortical morphological changes in multiple sclerosis patients: a study of cortical thickness, sulcal depth, and local gyrification index. aug: au: Genç, Barış Aslan, Kerim Şen, Sedat İncesu, Lütfi affil: Department of Radiology, Samsun Education and Research Hospital, İlkadım, 55060, Samsun, Turkey sug: subj: Multiple Sclerosis Physiopathology Brain Cortical Thickness Evaluation Cerebral Cortex Pathology Prefrontal Cortex Pathology Disease Remission Brain Anatomy and Histology Human Male Female Adolescence Young Adult Middle Age Aged Data Analysis Software Descriptive Statistics Tomography, X-Ray Computed Adolescent: 13-18 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Purpose: Multiple sclerosis (MS) is a disease that progresses not only with demyelination but also with neurodegeneration. One of the goals of drug treatment in MS is to prevent neurodegeneration. Cortical thickness (CT), sulcal depth (SD), and local gyrification index (LGI) are indicators related to neurodegeneration. The aim of this study is to investigate changes in CT, SD, and LGI in patients with relapsing-remitting MS (RRMS). Methods: T1 images of 74 RRMS patients and 65 healthy controls were used. T1 hypointense areas in RRMS patients were corrected using fully automated methods. CT, SD, and LGI were calculated for each patient. Results: RRMS patients showed widespread cortical thinning, especially in bilateral temporoparietal areas, decreased SD in bilateral supramarginal gyrus, superior temporal gyrus, postcentral gyrus, and transverse temporal gyrus, and decreased LGI, especially in the left posterior cingulate gyrus and insula. The decrease in cortical thickness was associated with the number of attacks and lesion volume. EDSS was related to CT in the right lingual, inferior temporal, and fusiform gyrus. The LGI was correlated with T2 lesion volume in bilateral insula, with EDSS in the right insula and transverse and superior temporal gyri, and with the number of attacks in the right paracentral gyrus and pre-cuneus. However, SD did not show any correlation with EDSS, T2 lesion volume, or the number of attacks. Conclusion: Our results demonstrate widespread cortical thinning, decreased sulcal depth in local areas, and decreased gyrification in folds in RRMS patients, which are related to clinical parameters. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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