Lipid Profile, Nutritional Status and Severity Biomarkers in Adults With Sickle Cell Anemia.
BACKGROUND: Lipid alterations have been described in sickle cell anemia (SCA), but their association with the disease severity is not fully understood and their correlation with the nutritional status of this population has not been widely studied. OBJECTIVES: This study aimed to assess the lipid pr...
| Publicado en: | Plasmatology Vol. 17; pp. 1 - 9 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
8/13/2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=169949416&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 169949416 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 26348535 MXRV jtl: Plasmatology issn: 26348535 maglogo: Y pubinfo: dt: 8/13/2023 vid: 17 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 169949416 169949416 169949416 10.1177/26348535231193889 169949416 ppf: 1 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Lipid Profile, Nutritional Status and Severity Biomarkers in Adults With Sickle Cell Anemia. aug: au: Pereira Gomes, Ingrid Cristiane Costa Machado Teles, João Pedro Sousa Coelho, Anny Catarina Passos Cruz, Maria Carollyne Costa de Albuquerque, Lindemberg Carvalho, Mariana Amaral Castro dos Santos, Paulo Herlan Nolasco dos Santos, Sérgio Cipolotti, Rosana affil: Health Sciences Postgraduate Program, 74391Federal University of Sergipe, Aracaju, SE, Brazil sug: subj: Lipids Analysis Anemia, Sickle Cell In Adulthood Nutritional Status Severity of Illness Biological Markers Macronutrients Food Intake Human Male Female Adult Anthropometry Cross Sectional Studies Sociodemographic Factors Mann-Whitney U Test Spearman's Rank Correlation Coefficient Carbohydrates Lipoproteins, HDL Triglycerides Hemoglobins Analysis Hematocrit Evaluation Hemolysis Adult: 19-44 years Male Female ab: BACKGROUND: Lipid alterations have been described in sickle cell anemia (SCA), but their association with the disease severity is not fully understood and their correlation with the nutritional status of this population has not been widely studied. OBJECTIVES: This study aimed to assess the lipid profile and its relation with the nutritional status, including anthropometric characteristics and daily macronutrient intake, and with the severity biomarkers in adults with SCA in a steady state. DESIGN: Cross-sectional study METHODS: This was an analytical cross-sectional study with 55 adults with SCA and 60 members of the control group. Sociodemographic, anthropometric, nutritional, and laboratory data were collected between March 2019 and June 2020. Mann–Whitney test was used to compare groups and Spearman's correlation coefficient was used to test the relation between variables. RESULTS: The SCA group presented higher calorie, protein, and carbohydrate intake, lower levels of high-density lipoprotein-cholesterol (HDL-c), and a higher triglyceride (TG)/HDL-c ratio than the control. HDL-c showed a positive correlation with hemoglobin and hematocrit (HcT) and a negative correlation with indirect bilirubin and lactate dehydrogenase (LDH). The TG/HDL-c ratio was positively linked with reticulocyte count, LDH, and leukocyte count and negatively linked with Hb. CONCLUSIONS: The study findings showed hypocholesterolemia in SCA and its independent correlation with macronutrient intake. The links of HDL-c and TG/HDL-c ratio with hemolysis indices indicate that they are easily accessible, low-cost markers capable of predicting SCA severity. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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