Sesquiterpene lactones from Artemisia verlotorum and their anti-inflammatory activities.
Seven new sesquiterpenoids (1 – 7) and 19 known analogues were isolated from the whole plant of Artemisia verlotorum. Their structures were determined by extensive analysis of 1D and 2D NMR and HRESIMS data, electronic circular dichroism (ECD) spectra, density functional theory (DFT) NMR calculation...
| Publicado en: | Fitoterapia Vol. 169 |
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| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Elsevier B.V.
Sep2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=169969110&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 169969110 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0367326X JF4 jtl: Fitoterapia issn: 0367326X maglogo: N pubinfo: dt: Sep2023 vid: 169 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 169969110 10.1016/j.fitote.2023.105560 169969110 ppct: 1 formats: tig: atl: Sesquiterpene lactones from Artemisia verlotorum and their anti-inflammatory activities. aug: au: Wang, Mengyu Yang, Yue Ke, Changqiang Yao, Sheng Feng, Zheling Tang, Chunping Ye, Yang affil: School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China sug: subj: Mugwort Therapeutic Use Hydrocarbons Therapeutic Use Antiinflammatory Agents Therapeutic Use Lactones Therapeutic Use Hydrocarbons Analysis Cytological Techniques Crystallography In Vitro Studies Macrophages Nuclear Physics Phytochemicals Therapeutic Use ab: Seven new sesquiterpenoids (1 – 7) and 19 known analogues were isolated from the whole plant of Artemisia verlotorum. Their structures were determined by extensive analysis of 1D and 2D NMR and HRESIMS data, electronic circular dichroism (ECD) spectra, density functional theory (DFT) NMR calculations, and time dependent density functional theory (TDDFT) ECD calculations. The absolute configurations of 1 , 3 , 5 and 7 were confirmed by single crystal X-ray diffraction experiments. Compounds 1 and 2 possess a rarely reported 5/8-bicyclic skeleton, while both compounds 3 and 4 were uncommon iphionane-type sesquiterpenoids. Eudesmane sesquiterpenoids (5 – 17) reported in this study are all 7,8- cis -lactones, of which, compound 7 represents the first eudesmane sesquiterpene with an oxygen bridge connecting C-5 and C-11. All the compounds were tested in vitro for their anti-inflammatory activities in LPS-stimulated RAW 264.7 murine macrophages. Compound 18 showed a potent inhibitory effect on NO production, with IC 50 values of 3.08 ± 0.61 μ M. [Display omitted] pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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