Association of genetic polymorphisms with mercapturic acids in the urine of young healthy subjects before and after exposure to outdoor air pollution.
We aimed to identify the relationship between variations in metabolic genes and human urinary changes in mercapturic acids (MAs), including CEMA, HMPMA, SPMA, HPMA and HEMA, before and after air pollution exposure. Genotype detection for 47 relevant single nucleotide polymorphisms (SNPs) collected b...
| Publicado en: | International Journal of Environmental Health Research Vol. 33; no. 9; pp. 936 - 949 |
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| Autores principales: | , , , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Sep2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=169995235&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 169995235 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09603123 57L jtl: International Journal of Environmental Health Research issn: 09603123 maglogo: Y pubinfo: dt: Sep2023 vid: 33 iid: 9 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 169995235 156494240 169995235 169995235 10.1080/09603123.2022.2066068 169995235 ppf: 936 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Association of genetic polymorphisms with mercapturic acids in the urine of young healthy subjects before and after exposure to outdoor air pollution. aug: au: Song, Wenping Bian, Lingjie Xiong, Mengran Duan, Yuanyuan Wang, Yi Zhang, Xia Li, Biao Dai, Yulong Lu, Jiawei Li, Meng Liu, Zhiguo Liu, Shigang Zhang, Li Yao, Hongjuan Shao, Rongguang Li, Guangxi Li, Liang affil: Department of Pharmacy, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China sug: subj: Air Pollution Environmental Exposure Polymorphism, Single Nucleotide Acetylcysteine Urine Human Male Female Adolescence Adult Middle Age Aged Genotype Polymorphism, Genetic Gene Expression Chromatography, Liquid Mass Spectrometry Lung Neoplasms Prognosis Disease Susceptibility Descriptive Statistics Pearson's Correlation Coefficient Funding Source Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: We aimed to identify the relationship between variations in metabolic genes and human urinary changes in mercapturic acids (MAs), including CEMA, HMPMA, SPMA, HPMA and HEMA, before and after air pollution exposure. Genotype detection for 47 relevant single nucleotide polymorphisms (SNPs) collected by literature research was performed. Five MAs expression levels in the urinary samples of 50 young healthy individuals with short-term exposure to clean, polluted and purified air at five time points were detected by targeted online solid-phase extraction liquid chromatography tandem mass spectrometry (SPE-LC-MS/MS), followed with associations of SNPs with MAs changes. Difference in MAs between polluted and clean/purified air was significantly associated with 21 SNPs mapped into 9 genes. Five SNPs in GSTP1 showed the most prominent association with the changes in SPMA expression, indicating that those SNPs in GSTP1 and SPMA might serve as biomarkers for susceptibility and the prognosis of lung cancer. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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