Niosome as an Effective Nanoscale Solution for the Treatment of Microbial Infections.
Numerous disorders go untreated owing to a lack of a suitable drug delivery technology or an appropriate therapeutic moiety, particularly when toxicities and side effects are a major concern. Treatment options for microbiological infections are not fulfilled owing to significant adverse effects or e...
| Publicado en: | BioMed Research International pp. 1 - 19 |
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| Autores principales: | , , , , , , |
| Formato: | pictorial review tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
8/16/2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=170021009&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 170021009 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 8/16/2023 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 170021009 170021009 170021009 10.1155/2023/9933283 170021009 ppf: 1 ppct: 18 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Niosome as an Effective Nanoscale Solution for the Treatment of Microbial Infections. aug: au: Barani, Mahmood Paknia, Fatemeh Roostaee, Maryam Kavyani, Batoul Kalantar-Neyestanaki, Davood Ajalli, Narges Amirbeigi, Alireza affil: Medical Mycology and Bacteriology Research Center, Kerman University of Medical Sciences, Kerman, Iran sug: subj: Drug Delivery Systems Methods Bacterial Infections Drug Therapy Nanoparticles Utilization Treatment Outcomes World Health Pseudomonas Infections Drug Therapy Combined Modality Therapy ab: Numerous disorders go untreated owing to a lack of a suitable drug delivery technology or an appropriate therapeutic moiety, particularly when toxicities and side effects are a major concern. Treatment options for microbiological infections are not fulfilled owing to significant adverse effects or extended therapeutic options. Advanced therapy options, such as active targeting, may be preferable to traditional ways of treating infectious diseases. Niosomes can be defined as microscopic lamellar molecules formed by a mixture of cholesterol, nonionic surfactants (alkyl or dialkyl polyglycerol ethers), and sometimes charge-inducing agents. These molecules comprise both hydrophilic and hydrophobic moieties of varying solubilities. In this review, several pathogenic microbes such as Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, Plasmodium, Leishmania, and Candida spp. have been evaluated. Also, the development of a proper niosomal formulation for the required application was discussed. This review also reviews that an optimal formulation is dependent on several aspects, including the choice of nonionic surfactant, fabrication process, and fabrication parameters. Finally, this review will give information on the effectiveness of niosomes in treating acute microbial infections, the mechanism of action of niosomes in combating microbial pathogens, and the advantages of using niosomes over other treatment modalities. pubtype: Academic Journal doctype: pictorial review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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