Memory Impairing Effect of Propranolol on Consolidation and Reconsolidation for Various Learning Tasks.

Newly acquired memory traces have been thought to become stable and resistant to interruption after they are stored in long-term memory. However, according to a recent research drugs such as betaadrenergic receptor antagonists enable memories to be updated and rewritten when administered during cons...

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Publicado en:Archives of Neuropsychiatry / Nöropsikiyatri Arşivi Vol. 60; no. 3; pp. 271 - 283
Autores principales: İLHAN, Çınar Furkan, KIŞLAL, Sezen
Formato: research systematic review tables/charts Journal Article
Publicado: Turkish Association of Neuropsychiatry Sep2023
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Sep2023
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      pub: Turkish Association of Neuropsychiatry
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        atl: Memory Impairing Effect of Propranolol on Consolidation and Reconsolidation for Various Learning Tasks.
      aug:
        au:
          İLHAN, Çınar Furkan
          KIŞLAL, Sezen
        affil: Middle East Technical University, Institute of Social Sciences, Department of Psychology, Ankara, Turkey
      sug:
        subj:
          Memory Disorders
          Propranolol Adverse Effects
          Learning
          Task Performance and Analysis
          Adrenergic beta-Agonists
          Animal Studies
          Propranolol Administration and Dosage
          Proteins Metabolism
          Psychological Distress
          Behavior, Addictive
          Rats
      ab: Newly acquired memory traces have been thought to become stable and resistant to interruption after they are stored in long-term memory. However, according to a recent research drugs such as betaadrenergic receptor antagonists enable memories to be updated and rewritten when administered during consolidation and reconsolidation. Propranolol is a widely used beta-adrenergic receptor antagonist that disrupts the consolidation and reconsolidation processes of memory formation as it inhibits protein synthesis in the central nervous system. This review aims to discuss the memory impairing effect of the systemic and intracerebral administration of propranolol during the consolidation and reconsolidation processes associated with different learning tasks. In doing so, this review will help elucidate the effects of propranolol on different stages of memory formation. Since learning and maladaptive memories underpin some of the most common psychological disorders, such as phobias, post-traumatic stress disorder, addiction, drugseeking behavior, and so on, a thorough understanding of propranolol's memory-impairing effect has significant clinical value and the potential to help people suffering from these disorders.
      pubtype: Academic Journal
      doctype:
        research
        systematic review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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