Prevalence and causative drugs of drug-induced Parkinsonism in pediatric patients.
Although several studies provided evidence on the epidemiology of drug-induced Parkinsonism (DIP) and its causative drugs, it is still limited in pediatrics. This study aimed to investigate the prevalence and risk of DIP in pediatrics. We used the Health Insurance Review and Assessment Service–Pedia...
| Publicado en: | European Child & Adolescent Psychiatry Vol. 32; no. 9; pp. 1805 - 1815 |
|---|---|
| Autores principales: | , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Sep2023
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=170716029&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 170716029 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Sep2023 vid: 32 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 170716029 163019475 170716029 170716029 10.1007/s00787-023-02207-7 170716029 ppf: 1805 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Prevalence and causative drugs of drug-induced Parkinsonism in pediatric patients. aug: au: Jeon, Soo Min Lee, Yu Jin Kwon, Jin-Won affil: College of Pharmacy, Jeju National University, Jeju, South Korea sug: subj: Parkinsonian Disorders Chemically Induced Parkinsonian Disorders Epidemiology Parkinsonian Disorders Risk Factors Risk Assessment Pediatrics Antipsychotic Agents Adverse Effects Human Prevalence Crossover Design Odds Ratio Confidence Intervals Logistic Regression Child Adolescence Young Adult Mental Disorders Drug Therapy Comorbidity Antipsychotic Agents Administration and Dosage Adverse Drug Event Parkinsonian Disorders Etiology Funding Source Child: 6-12 years Adolescent: 13-18 years ab: Although several studies provided evidence on the epidemiology of drug-induced Parkinsonism (DIP) and its causative drugs, it is still limited in pediatrics. This study aimed to investigate the prevalence and risk of DIP in pediatrics. We used the Health Insurance Review and Assessment Service–Pediatric Patients Sample in Korea between 2010 and 2017 to estimate the annual prevalence of DIP and causative drug use using a cross-sectional design. The risk of DIP associated with causative drugs was evaluated using a case-crossover design. Adjusted odds ratios (aOR) with 95% confidence intervals (CI) were calculated using a conditional logistic regression. A total of 2925 pediatric patients had diagnosed with DIP from 2010 to 2017. Most patients were aged between 12 and19 years old, and 99.8% had any diagnosis of mental health disorder (MHD). During the study period, the prevalence of DIP increased by 10.0-fold from 2010 to 2017. All causative drugs showed a corresponding increase in their use, with atypical antipsychotics being the most prominent (increase ratio, 2.07). For both in the prevalence of DIP and atypical antipsychotic use, the increment was much bigger in patients with non-psychotic MHD than that in patients with psychotic MHD. In the case-crossover study, antipsychotics showed the largest aOR with DIP. Risperidone among antipsychotics showed the highest risk for DIP (aOR = 7.09, 95% CI = 3.83–13.09), followed by aripiprazole (aOR = 5.03, 95% CI = 2.88–8.80). This study suggests that the increase in DIP prevalence in pediatric patients might be because of the increased use of atypical antipsychotics. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|