A Feasibility Study of Diabetic Retinopathy Detection in Type II Diabetic Patients Based on Explainable Artificial Intelligence.

Diabetic retinopathy (DR) is vision impairment and a life-threatening condition for diabetic patients. Especially type II diabetic people have higher chances of getting retinal problems. Hence, early prediction of DR is necessary for preventing the diabetic patients from vision impairment. The main...

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Publicado en:Journal of Medical Systems Vol. 47; no. 1; pp. 1 - 22
Autores principales: Lalithadevi, B., Krishnaveni, S., Gnanadurai, J. Samuel Cornelius
Formato: equations & formulas pictorial research tables/charts Journal Article
Publicado: Springer Nature 8/8/2023
Acceso en línea:Ver este registro en EBSCOhost
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      dt: 8/8/2023
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      pub: Springer Nature
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          Lalithadevi, B.
          Krishnaveni, S.
          Gnanadurai, J. Samuel Cornelius
        affil: Department of Computational Intelligence, SRM Institute of Science and Technology, Kattankulathur, Chennai, TN, India
      sug:
        subj:
          Diabetic Retinopathy Diagnosis
          Diabetes Mellitus, Type 2
          Artificial Intelligence
          Early Diagnosis
          Diabetic Retinopathy Risk Factors
          Risk Assessment
          Prediction Models
          Human
          Diabetic Patients
          Analytic Research
          Questionnaires
          Health Screening
          Random Sample
          Adult
          Middle Age
          Aged
          Severity of Illness
          Blood Glucose
          Machine Learning
          Descriptive Statistics
          Inferential Statistics
          Algorithms
          Ophthalmologists
          Male
          Female
          Analysis of Variance
          Data Analysis Software
          Regression
          Aged, 80 and Over
          Body Mass Index
          Factor Analysis
          Chi Square Test
          Behavioral and Mental Disorders
          Adult: 19-44 years
          Middle Aged: 45-64 years
          Aged: 65+ years
          Aged, 80 & over
          Male
          Female
      ab: Diabetic retinopathy (DR) is vision impairment and a life-threatening condition for diabetic patients. Especially type II diabetic people have higher chances of getting retinal problems. Hence, early prediction of DR is necessary for preventing the diabetic patients from vision impairment. The main aim of this feasibility study is to identify the most critical risk features that could lead to diabetic retinopathy. This study investigated type II diabetic patients' socio-analytical, diabetes, behavioral, and clinical risk factors. We conducted a self-individual questionnaire session for all participants. Our questionnaire asked about the reliability of results, feeling comfortable during the screening test, willingness to participate in future screenings, overall perspective, and satisfaction with the DR screening test. We proposed a random forest model for predicting the prevalence of DR risk among diabetics. Further explanations of the model were conducted using more robust SHAP eXplainable Artificial Intelligence (XAI) tools. The SHAP method makes it possible to understand how input variables interact with their representative output records, as well as how input variables are ranked. In addition, various descriptive and inferential statistical analyses were performed on the data and evaluated the significant relationship between the factors discussed above via hypothesis testing. This feasibility study involved 172 type II diabetic patients (73 males and 99 females). Therefore, we found that 81 (47.09%) out of 172 participants had referable DR. The average age of the patients was determined as 55.08, with a standard deviation of ± 9.770 (ranging from 40 to 79). Type II patients were affected by mild, moderate, severe, and advanced proliferative diabetic retinopathy (PDR) stages with 23.83%, 13.95%, 5.81%, and 3.48%, respectively, of the total samples. The developed RF model obtained high accuracy of 94.9% using clinical dataset. Our results showed that the formation of tiny microminiature lesions was noticeable in type II diabetic patients with aged people, abnormal blood glucose levels, and prolonged diabetes duration.
      pubtype: Academic Journal
      doctype:
        equations & formulas
        pictorial
        research
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        Journal Article
      ougenre: Article
    language: English
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