Layer-Specific Changes in the Prefrontal Glia/Neuron Ratio Characterizes Patches of Gene Expression Disorganization in Children with Autism.
Autism spectrum disorder (ASD) is manifested by abnormal cell numbers and patches of gene expression disruption in higher-order brain regions. Here, we investigated whether layer-specific changes in glia/neuron ratios (GNR) characterize patches in the dorsolateral prefrontal cortex (DL-PFC) of child...
| Publicado en: | Journal of Autism & Developmental Disorders Vol. 53; no. 9; pp. 3648 - 3659 |
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| Autores principales: | , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Sep2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=170899320&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 170899320 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01623257 AUT jtl: Journal of Autism & Developmental Disorders issn: 01623257 maglogo: N pubinfo: dt: Sep2023 vid: 53 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 170899320 157459165 170899320 170899320 10.1007/s10803-022-05626-8 170899320 ppf: 3648 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Layer-Specific Changes in the Prefrontal Glia/Neuron Ratio Characterizes Patches of Gene Expression Disorganization in Children with Autism. aug: au: Rabelo, Livia Nascimento Queiroz, José Pablo Gonçalves Castro, Carla Cristina Miranda Silva, Sayonara Pereira Campos, Laura Damasceno Silva, Larissa Camila Nascimento, Ezequiel Batista Martínez-Cerdeño, Veronica Fiuza, Felipe Porto affil: Graduate Program in Neuroengineering, Edmond and Lily Safra International Institute of Neuroscience, Santos Dumont Institute, 59280-000, Macaíba, RN, Brazil sug: subj: Prefrontal Cortex Pathology Glial Cells Physiopathology Neurons Physiopathology Gene Expression Children with Disabilities Autism Spectrum Disorder Physiopathology Human Funding Source Child, Preschool Child Adolescence Male Female Digital Imaging Neuroradiography Cadaver Neurodevelopment Child, Preschool: 2-5 years Child: 6-12 years Adolescent: 13-18 years Male Female ab: Autism spectrum disorder (ASD) is manifested by abnormal cell numbers and patches of gene expression disruption in higher-order brain regions. Here, we investigated whether layer-specific changes in glia/neuron ratios (GNR) characterize patches in the dorsolateral prefrontal cortex (DL-PFC) of children with ASD. We analyzed high-resolution digital images of postmortem human brains from 11 ASD and 11 non-ASD children obtained from the Autism Study of the Allen Human Brain Atlas. We found the GNR is overall reduced in the ASD DL-PFC. Moreover, layers II-III belonging to patches presented a lower GNR in comparison with layers V-VI. We here provide a new insight into how brain cells are arranged within patches that contributes to elucidate how neurodevelopmental programs are altered in ASD. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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