The association of low birthweight and prematurity on outcomes in children and adults with nephrotic syndrome—a NEPTUNE cohort study.
Background: In single-center studies, both preterm birth and low birth weight (LBW) are associated with worse outcomes in childhood nephrotic syndrome. Using the Nephrotic Syndrome Study Network (NEPTUNE) observational cohort, we tested the hypothesis that in patients with nephrotic syndrome, hypert...
| Publicado en: | Pediatric Nephrology Vol. 38; no. 10; pp. 3297 - 3309 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Oct2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=170899537&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 170899537 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0931041X EF1 jtl: Pediatric Nephrology issn: 0931041X maglogo: N pubinfo: dt: Oct2023 vid: 38 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 170899537 163504610 170899537 170899537 10.1007/s00467-023-05876-3 170899537 ppf: 3297 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The association of low birthweight and prematurity on outcomes in children and adults with nephrotic syndrome—a NEPTUNE cohort study. aug: au: Hingorani, Sangeeta Gibson, Keisha L. Xie, Yuping Wang, Yujie Eddy, Sean Hartman, John Sampson, Matthew Cassol, Clarissa Thomas, David Gipson, Debbie S. Trachtman, Howard Srivastava, Tarak Reidy, Kimberly Massengill, S. Lo, L. Dell, K. Sedor, J. Martin, B. Lemley, K. Fajardo, C. affil: University of Washington, Seattle Children's Hospital, Seattle, WA, USA sug: subj: Nephrotic Syndrome Therapy Nephrotic Syndrome Therapy Infant, Low Birth Weight Infant, Premature Outcomes (Health Care) Evaluation Human Descriptive Statistics Data Analysis Software Confidence Intervals Prospective Studies Nonexperimental Studies Odds Ratio Male Female Child Adolescence Young Adult Adult Biological Markers T-Tests Child: 6-12 years Adolescent: 13-18 years Adult: 19-44 years Male Female ab: Background: In single-center studies, both preterm birth and low birth weight (LBW) are associated with worse outcomes in childhood nephrotic syndrome. Using the Nephrotic Syndrome Study Network (NEPTUNE) observational cohort, we tested the hypothesis that in patients with nephrotic syndrome, hypertension, proteinuria status, and disease progression would be more prevalent and more severe in subjects with LBW and prematurity singly or in combination (LBW/prematurity). Methods: Three hundred fifty-nine adults and children with focal segmental glomerulosclerosis (FSGS) or minimal change disease (MCD) and available birth history were included. Estimated glomerular filtration rate (eGFR) decline and remission status were primary outcomes, and secondary outcomes were kidney histopathology, kidney gene expression, and urinary biomarkers. Logistic regression was used to identify associations with LBW/prematurity and these outcomes. Results: We did not find an association between LBW/prematurity and remission of proteinuria. However, LBW/prematurity was associated with greater decline in eGFR. This decline in eGFR was partially explained by the association of LBW/prematurity with APOL1 high-risk alleles, but the association remained after adjustment. There were no differences in kidney histopathology or gene expression in the LBW/prematurity group compared to normal birth weight/term birth. Conclusion: LBW and premature babies who develop nephrotic syndrome have a more rapid decline in kidney function. We did not identify clinical or laboratory features that distinguished the groups. Additional studies in larger groups are needed to fully ascertain the effects of (LBW) and prematurity alone or in combination on kidney function in the setting of nephrotic syndrome. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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