Are medication effects on subjective response to alcohol and cue-induced craving associated? A meta regression study.
Rationale: Alcohol administration and cue-reactivity paradigms are frequently used to screen for the initial efficacy of medications for alcohol use disorder (AUD). While medication effects on the primary outcomes for these paradigms are assumed to be qualitatively related, there is a critical lack...
| Publicado en: | Psychopharmacology Vol. 240; no. 9; pp. 1921 - 1931 |
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| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Sep2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=171309591&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 171309591 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: Sep2023 vid: 240 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 171309591 164898784 10.1007/s00213-023-06409-4 171309591 ppf: 1921 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Are medication effects on subjective response to alcohol and cue-induced craving associated? A meta regression study. aug: au: Ray, Lara A. Nieto, Steven J. Meredith, Lindsay R. Burnette, Elizabeth Donato, Suzanna Magill, Molly Du, Han affil: Department of Psychology, University of California at Los Angeles, Box 951563, 1285 Franz Hall, 90095-1563, Los Angeles, CA, USA sug: ab: Rationale: Alcohol administration and cue-reactivity paradigms are frequently used to screen for the initial efficacy of medications for alcohol use disorder (AUD). While medication effects on the primary outcomes for these paradigms are assumed to be qualitatively related, there is a critical lack of quantitative evidence to support this hypothesis. Objectives: The study aims to test the relationship between medication effect sizes on subjective response to alcohol administration and medication effect sizes for cue-induced craving to cue exposure, using meta-analysis. Methods: Systematic literature searches were conducted to identify randomized trials, wherein AUD medications were tested using the alcohol administration and/or cue-reactivity paradigms. From these studies, descriptive statistics were collected to compute medication effect sizes on the primary outcomes for each respective paradigm. With medication as the unit of analysis, medication effect sizes in alcohol administration studies were compared with medication effect sizes in cue-reactivity studies using the Williamson-York regression which allows for meta-regression across independent samples. Results: Medication effect sizes on alcohol-induced stimulation and alcohol-induced craving were not significantly associated with medication effect sizes on cue-induced alcohol craving (k stimulation = 10 medications, β ^ = 0.272 SE = 0.263 , p = 0.150 and k craving = 11 medications, β ^ = 0.217 (SE = 0.237), p = 0.181 ), respectively. Medication effect sizes on alcohol-induced sedation were significantly associated with medication effects on cue-induced craving (k = 10 medications, β ^ = - 0.600 (SE = 0.258), p = 0.010 ), such that medications that increased alcohol-induced sedation were more likely to reduce cue-induced alcohol craving. Conclusions: With the exception of alcohol-induced sedation, there is little quantitative evidence of medication effects on subjective response domains measured during alcohol administration parallel medication effects on cue-induced alcohol craving. To provide additional context to the current study, future work should examine whether cue-reactivity findings predict clinical trial outcomes. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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