New horizons in cognitive and functional impairment as a consequence of cerebral small vessel disease.
Cerebral small vessel disease (cSVD) is a frequent finding in imaging of the brain in older adults, especially in the concomitance of cardiovascular disease risk factors. Despite the well-established link between cSVD and (vascular) cognitive impairment (VCI), it remains uncertain how and when these...
| Published in: | Age & Ageing Vol. 52; no. 8; pp. 1 - 10 |
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| Main Authors: | , , , , |
| Format: | Article |
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Oxford University Press / USA
Aug2023
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=171352360&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 171352360 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Aug2023 vid: 52 iid: 8 pid: 622 pub: Oxford University Press / USA artinfo: ui: 171352360 10.1093/ageing/afad148 ppf: 1 ppct: 9 formats: tig: atl: New horizons in cognitive and functional impairment as a consequence of cerebral small vessel disease. aug: au: Tap, Lisanne Vernooij, Meike W Wolters, Frank van den Berg, Esther Mattace-Raso, Francesco U S affil: Department of Internal Medicine, Section of Geriatric Medicine and Alzheimer Center Erasmus MC, Erasmus MC University Medical Center , Rotterdam , The Netherlands Department of Radiology and Nuclear Medicine and Alzheimer Center Erasmus MC, Erasmus MC University Medical Center , Rotterdam , The Netherlands Department of Epidemiology and Alzheimer Center Erasmus MC, Erasmus MC University Medical Center , Rotterdam , The Netherlands Department of Neurology and Alzheimer Center Erasmus MC, Erasmus MC University Medical Center , Rotterdam , The Netherlands su: Cognition disorders diagnosis Cerebral small vessel diseases Geriatric assessment Neuropsychological tests Neuroradiology sug: subj: Cognition disorders diagnosis Cerebral small vessel diseases Geriatric assessment Neuropsychological tests Neuroradiology keyword: cerebral small vessel disease comprehensive geriatric assessment neuroimaging neuropsychological assessment older people vascular cognitive impairment cerebral small vessel disease comprehensive geriatric assessment neuroimaging neuropsychological assessment older people vascular cognitive impairment ab: Cerebral small vessel disease (cSVD) is a frequent finding in imaging of the brain in older adults, especially in the concomitance of cardiovascular disease risk factors. Despite the well-established link between cSVD and (vascular) cognitive impairment (VCI), it remains uncertain how and when these vascular alterations lead to cognitive decline. The extent of acknowledged markers of cSVD is at best modestly associated with the severity of clinical symptoms, but technological advances increasingly allow to identify and quantify the extent and perhaps also the functional impact of cSVD more accurately. This will facilitate a more accurate diagnosis of VCI, against the backdrop of concomitant other neurodegenerative pathology, and help to identify persons with the greatest risk of cognitive and functional deterioration. In this study, we discuss how better assessment of cSVD using refined neuropsychological and comprehensive geriatric assessment as well as modern image analysis techniques may improve diagnosis and possibly the prognosis of VCI. Finally, we discuss new avenues in the treatment of cSVD and outline how these contemporary insights into cSVD can contribute to optimise screening and treatment strategies in older adults with cognitive impairment and multimorbidity. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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