Increased elasticity of sucrose demand during hyperdopaminergic states in rats.
Rationale: Deficits in cost–benefit decision-making are a core feature of several psychiatric disorders, including substance addiction, eating disorders and bipolar disorder. Mesocorticolimbic dopamine signalling has been implicated in various processes related to cognition and reward, but its preci...
| Publicado en: | Psychopharmacology Vol. 239; no. 3; pp. 773 - 795 |
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| Autores principales: | , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Mar2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=171353533&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 171353533 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: Mar2022 vid: 239 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 171353533 154977837 10.1007/s00213-022-06068-x 171353533 ppf: 773 ppct: 22 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Increased elasticity of sucrose demand during hyperdopaminergic states in rats. aug: au: Minnaard, A. Maryse Luijendijk, Mieneke C. M. Baars, Annemarie M. Drost, Lisa Ramakers, Geert M. J. Adan, Roger A. H. Lesscher, Heidi M. B. Vanderschuren, Louk J. M. J. affil: Department of Population Health Sciences, Unit Animals in Science and Society, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands sug: ab: Rationale: Deficits in cost–benefit decision-making are a core feature of several psychiatric disorders, including substance addiction, eating disorders and bipolar disorder. Mesocorticolimbic dopamine signalling has been implicated in various processes related to cognition and reward, but its precise role in reward valuation and cost–benefit trade-off decisions remains incompletely understood. Objectives: We assessed the role of mesocorticolimbic dopamine signalling in the relationship between price and consumption of sucrose, to better understand its role in cost–benefit decisions. Methods: Dopamine neurons in the ventral tegmental area (VTA) were chemogenetically activated in rats, and a behavioural economics approach was used to quantify the relationship between price and consumption of sucrose. Motivation for sucrose was also assessed under a progressive ratio (PR) schedule of reinforcement. To further gauge the role of dopamine in cost–benefit trade-offs for sucrose, the effects of treatment with D-amphetamine and the dopamine receptor antagonist alpha-flupentixol were assessed. Results: Chemogenetic activation of VTA dopamine neurons increased demand elasticity, while responding for sucrose under a PR schedule of reinforcement was augmented upon stimulation of VTA dopamine neurons. Treatment with amphetamine partially replicated the effects of chemogenetic dopamine neuron activation, whereas treatment with alpha-flupentixol reduced free consumption of sucrose and had mixed effects on demand elasticity. Conclusions: Stimulation of mesocorticolimbic dopaminergic neurotransmission altered cost–benefit trade-offs in a complex manner. It reduced the essential value of palatable food, increased incentive motivation and left free consumption unaltered. Together, these findings imply that mesocorticolimbic dopamine signalling differentially influences distinct components of cost expenditure processes aimed at obtaining rewards. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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